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Survival of humanized plasminogen AlbPLG1 mice following subcutaneous challenge with 1.3 × 108 CFU of GAS 5448 on day 42 (n = 10 for the PBS and J8-ADI groups; n = 9 for the Combo#5 and ΔGAC-ADI groups; n = 8 for the M1 group). Curves were compared using the log rank (Mantel-Cox) test (***, P < 0.001).
