Table 1.
Baseline characteristics of populations of patients who survived acute myocardial infarction (AMI) defined in this study and equivalent characteristics from PEGASUS-TIMI-54 trial. Figures are numbers (percentage) unless stated otherwise
| CALIBER observational data from population of England | PEGASUS-TIMI-54 placebo group (n=7067) | |||
|---|---|---|---|---|
| All post-MI survivors “real world” (n=7328) | Met trial inclusion criteria “high risk” (n=5279) | Met trial inclusion and exclusion criteria “target” (n=1676) | ||
| Index myocardial infarction: | ||||
| STEMI | 2827 (39.1) | 1809 (34.3) | 599 (35.7) | 3809 (54.0) |
| Non-STEMI | 4411 (60.9) | 3470 (65.7) | 1077 (64.3) | 2843 (40.3) |
| Median (IQR) years after index AMI | 1.0 (1-1) | 1.0 (1-1) | 1.0 (1-1) | 1.7 (1.2-1.3) |
| Baseline characteristics: | ||||
| Mean (SD) age (years) | 69.6 (13.0) | 75.3 (9.5) | 77.0 (9.6) | 65.4 (8.3) |
| Women | 2461 (34.0) | 2088 (39.6) | 814 (48.6) | 1717 (24.3) |
| White | 5924 (94.4) | 4174 (94.2) | 1350 (95.7) | 6124 (86.7) |
| Mean (SD) weight (kg)* | 79.6 (17.5) | 77.2 (16.8) | 74.8 (17.4) | 81.8 (16.6) |
| Hypertension | 4543 (62.8) | 3677 (69.7) | 1090 (65.0) | 5484 (77.6) |
| Hypercholesterolemia | NA | NA | NA | 5451 (77.1) |
| Current smoker* | 1065 (15.7) | 572 (11.6) | 162 (10.6) | 1143 (16.2) |
| Diabetes mellitus | 1522 (21.0) | 1449 (27.5) | 392 (24.4) | 2257 (31.9) |
| Multivessel coronary artery disease | NA | NA | NA | 4213 (59.6) |
| History of PCI† | 3025 (41.8) | 1840 (34.9) | 391 (23.3) | 5837/7066 (82.6) |
| More than one myocardial infarction | 830 (11.5) | 804 (15.2) | 191 (11.4) | 1188 (16.8) |
| Peripheral arterial disease | 449 (6.2) | 400 (7.6) | 101 (6.0) | 404 (5.7) |
| eGFR <60 mL/min/1.73m2* | 2402 (37.5) | 2383 (49.9) | 797 (52.3) | 1649 (23.6) |
| Drug treatment: | ||||
| Any aspirin | 5726 (79.1) | 4118 (78.0) | 1250 (74.6) | 7057 (99.9) |
| Clopidogrel | 3713 (51.3) | 2628 (49.8) | 0 (0) | NA |
| Statins | 6262 (86.5) | 4500 (85.2) | 1335 (79.7) | 6583 (93.2) |
| β blockers | 5098 (70.4) | 3574 (67.7) | 1065 (63.5) | 5878 (83.2) |
| ARBs/ACEIs | 5793 (80.0) | 4145 (78.5) | 1283 (76.6) | 5697 (80.6) |
STEMI=ST elevation myocardial infarction; IQR=interquartile range; NA=not available; PCI=percutaneous coronary intervention; eGFR=estimated glomerular filtration rate; ARBs=angiotensin II receptor blockers; ACEIs=angiotensin converting enzyme inhibitors.
*Information from CALIBER available for 65% for weight, 94% for smoking status, and 88% for eGFR.
†In past 365 days.