Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1982 Dec;45(12):1113–1118. doi: 10.1136/jnnp.45.12.1113

A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial

FB Gibberd 1,2,3,4, DM Park 1,2,3,4, G Scott 1,2,3,4, MJ Gawel 1,2,3,4, DE Fry 1,2,3,4, NGR Page 1,2,3,4, C Engler 1,2,3,4, JR English 1,2,3,4, F Clifford Rose 1,2,3,4
PMCID: PMC491693  PMID: 6819339

Abstract

A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described. There was no significant difference between the frequency of seizures in the two groups. The difficulties in comparing two anticonvulsants of similar efficacy are discussed particularly in relation to ethical problems, the selection of patients and trial design.

Full text

PDF
1113

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bowe J. C., Shersby B. J. Pheneturide in epilepsy: preliminary communication. Br J Clin Pract. 1973 May;27(5):174–176. [PubMed] [Google Scholar]
  2. Hershon H. I., Parsonage M. Comparative trial of diazepam and pheneturide in treatment of epilepsy. Lancet. 1969 Oct 25;2(7626):859–862. doi: 10.1016/s0140-6736(69)92324-1. [DOI] [PubMed] [Google Scholar]
  3. Papadopoulos A. S., Baylis E. M., Fry D. E., Marks V. A rapid micro-method for determining four anti-convulsant drugs by gas-liquid chromatography. Clin Chim Acta. 1973 Oct 12;48(2):135–141. doi: 10.1016/0009-8981(73)90358-6. [DOI] [PubMed] [Google Scholar]
  4. Vas C. J., Parsonage M. J. Treatment of intractable temporal lobe epilepsy with pheneturide. Acta Neurol Scand. 1967;43(5):580–586. doi: 10.1111/j.1600-0404.1967.tb05553.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES