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. 1983 Nov;46(11):1044–1046. doi: 10.1136/jnnp.46.11.1044

Treatment of menstrual migraine by oestradiol implants.

A L Magos, K J Zilkha, J W Studd
PMCID: PMC491742  PMID: 6686248

Abstract

The suppression of cyclical ovarian activity and the creation of constant oestradiol levels in blood by subcutaneous oestradiol implants has been used to treat 24 patients with menstrual migraine for up to five years. Twenty-three patients improved with treatment, 20 (83%) became completely or almost completely headache-free. Regular monthly periods were induced with cyclical oral progestogens. The treatment was not associated with any problems. The results support the concept that oestrogen withdrawal in the late luteal and menstrual phases of the ovarian cycle is the important precipitating factor in menstrual migraine, and such attacks can be prevented by suppressing the hormonal fluctuations associated with the ovarian cycle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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