Fig. 3.

Changes in protein expression profiles. The metaproteomic analysis PCO plot shows the similarity in the abundance of quantified proteins in each individual (Bray Curtis similarity; Bray and Curtis, 1957). An Analysis of Similarities (ANOSIM) revealed significant differences in protein abundance between groups with a global R of 0.668 at a significance level of 0.01%. Compared to the uninfected group, the Significant Percentages (SIMPER) analyses yielded an average dissimilarity of 82.22% in comparison to the VU group, 74.22% in comparison to the IR group and 72.31% in comparison to the INR group, with a cut off for low contributions at 90%. Symbol codes are included in the figure. The 6-weeks longitudinal samples, label as “_T” (for time), are incorporated in the PCA with empty symbols.