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. 1975 Aug;38(8):771–775. doi: 10.1136/jnnp.38.8.771

Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone.

P S Spencer, H H Schaumburg
PMCID: PMC492070  PMID: 171344

Abstract

Chronic exposure of rats to 2,5-hexanedione (CH3COCH2CH2COCH3), a major metabolite of the neurotoxic industrial solvent methyl n-buryl ketone (CH3COCH2CH2CH2CH3), has been shown to cause a clinical peripheral neuropathy with dying-back peripheral and central nervous system degeneration characterized by giant axonal swellings filled with neurofilaments. This pattern of disease is similar to that produced by methyl n-butyl ketone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asbury A. K., Gale M. K., Cox S. C., Baringer J. R., Berg B. O. Giant axonal neuropathy--a unique case with segmental neurofilamentous masses. Acta Neuropathol. 1972;20(3):237–247. doi: 10.1007/BF00686905. [DOI] [PubMed] [Google Scholar]
  2. Carpenter S., Karpati G., Andermann F., Gold R. Giant axonal neuropathy. A clinically and morphologically distinct neurological disease. Arch Neurol. 1974 Nov;31(5):312–316. doi: 10.1001/archneur.1974.00490410060005. [DOI] [PubMed] [Google Scholar]
  3. Cavanagh J. B. The significance of the "dying back" process in experimental and human neurological disease. Int Rev Exp Pathol. 1964;3:219–267. [PubMed] [Google Scholar]
  4. Duckett S., Williams N., Francis S. Peripheral neuropathy associated with inhalation of methyl-n-butyl ketone. Experientia. 1974 Nov 15;30(11):1283–1284. doi: 10.1007/BF01945188. [DOI] [PubMed] [Google Scholar]
  5. Korobkin R., Asbury A. K., Sumner A. J., Nielsen S. L. Glue-sniffing neuropathy. Arch Neurol. 1975 Mar;32(3):158–162. doi: 10.1001/archneur.1975.00490450038004. [DOI] [PubMed] [Google Scholar]
  6. Mendell J. R., Saida K., Ganansia M. F., Jackson D. B., Weiss H., Gardier R. W., Chrisman C., Allen N., Couri D., O'Neill J. Toxic polyneuropathy produced by methyl N-butyl ketone. Science. 1974 Aug 30;185(4153):787–789. doi: 10.1126/science.185.4153.787. [DOI] [PubMed] [Google Scholar]
  7. Prineas J. The pathogenesis of dying-back polyneuropathies. I. An ultrastructural study of experimental tri-ortho-cresyl phosphate intoxication in the cat. J Neuropathol Exp Neurol. 1969 Oct;28(4):571–597. doi: 10.1097/00005072-196910000-00003. [DOI] [PubMed] [Google Scholar]
  8. Schaumburg H. H., Wiśniewski H. M., Spencer P. S. Ultrastructural studies of the dying-back process. I. Peripheral nerve terminal and axon degeneration in systemic acrylamide intoxication. J Neuropathol Exp Neurol. 1974 Apr;33(2):260–284. doi: 10.1097/00005072-197404000-00006. [DOI] [PubMed] [Google Scholar]
  9. Spencer P. S., Schaumburg H. H. A review of acrylamide neurotoxicity. Part II. Experimental animal neurotoxicity and pathologic mechanisms. Can J Neurol Sci. 1974 Aug;1(3):152–169. doi: 10.1017/s0317167100119201. [DOI] [PubMed] [Google Scholar]
  10. Spencer P. S., Schaumburg H. H., Raleigh R. L., Terhaar C. J. Nervous system degeneration produced by the industrial solvent methyl n-butyl ketone. Arch Neurol. 1975 Apr;32(4):219–222. doi: 10.1001/archneur.1975.00490460035002. [DOI] [PubMed] [Google Scholar]
  11. Spencer P. S., Thomas P. K. Ultrastructural studies of the dying-back process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseases axons. J Neurocytol. 1974 Dec;3(6):763–783. doi: 10.1007/BF01097197. [DOI] [PubMed] [Google Scholar]

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