Abstract
A single fibre EMG study is presented from extensor digitorum communis muscle in sujbects aged 10 to 89 years. The average number of single muscle fibre action potentials generated by muscle fibres in the same motor unit within the uptake area of the electrode is used as a measure of the motor unit fibre density. The fibre density increases slowly during life with a faster progression after the age 70 years. The number of recordings indicating impaired nerve or neuromuscular impulse transmission increases at the same time. The findings indicate degenerative loss of motor neurones with aging, compensated for by reinnervation. The changes are relatively slight in the extensor digitorum communis muscle as compared with other muscles, permitting early pathological changes in this muscle to be recognized independently of age factors.
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Selected References
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- Brooke M. H., Engel W. K. The histographic analysis of human muscle biopsies with regard to fiber types. 4. Children's biopsies. Neurology. 1969 Jun;19(6):591–605. doi: 10.1212/wnl.19.6.591. [DOI] [PubMed] [Google Scholar]
- Brown W. F. A method for estimating the number of motor units in thenar muscles and the changes in motor unit count with ageing. J Neurol Neurosurg Psychiatry. 1972 Dec;35(6):845–852. doi: 10.1136/jnnp.35.6.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown W. F. Functional compensation of human motor units in health and disease. J Neurol Sci. 1973 Oct;20(2):199–209. doi: 10.1016/0022-510x(73)90030-0. [DOI] [PubMed] [Google Scholar]
- Campbell M. J., McComas A. J., Petito F. Physiological changes in ageing muscles. J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):174–182. doi: 10.1136/jnnp.36.2.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hakelius L., Stålberg E. Electromyographical studies of free autogenous muscle transplants in man. Scand J Plast Reconstr Surg. 1974;8(3):211–219. doi: 10.3109/02844317409084397. [DOI] [PubMed] [Google Scholar]
- Jennekens F. G., Tomlinson B. E., Walton J. N. Histochemical aspects of five limb muscles in old age. An autopsy study. J Neurol Sci. 1971 Nov;14(3):259–276. doi: 10.1016/0022-510x(71)90216-4. [DOI] [PubMed] [Google Scholar]
- Jennekens F. G., Tomlinson B. E., Walton J. N. The extensor digitorum brevis: histological and histochemical aspects. J Neurol Neurosurg Psychiatry. 1972 Feb;35(1):124–132. doi: 10.1136/jnnp.35.1.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Sullivan D. J., Swallow M. The fibre size and content of the radial and sural nerves. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):464–470. doi: 10.1136/jnnp.31.5.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SACCO G., BUCHTHAL F., ROSENFALCK P. Motor unit potentials at different ages. Arch Neurol. 1962 May;6:366–373. doi: 10.1001/archneur.1962.00450230028004. [DOI] [PubMed] [Google Scholar]
- Stålberg E., Ekstedt J., Broman A. The electromyographic jitter in normal human muscles. Electroencephalogr Clin Neurophysiol. 1971 Nov;31(5):429–438. doi: 10.1016/0013-4694(71)90164-7. [DOI] [PubMed] [Google Scholar]
- Stålberg E., Thiele B. Transmission block in terminal nerve twigs: a single fibre electromyographic finding in man. J Neurol Neurosurg Psychiatry. 1972 Feb;35(1):52–59. doi: 10.1136/jnnp.35.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thiele B., Stålberg E. The bimodal jitter: a single fibre electromyographic finding. J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):403–411. doi: 10.1136/jnnp.37.4.403. [DOI] [PMC free article] [PubMed] [Google Scholar]