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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1975 Oct;38(10):1003–1007. doi: 10.1136/jnnp.38.10.1003

Hypothalamic and pancreatic lesions with diabetes mellitus.

S Shuangshoti, P Samranvej
PMCID: PMC492136  PMID: 1104774

Abstract

A case is reported of a neoplasm of mixed mesenchymal and neuroepithelial origin consisting of plasmacytoma, lymphoma, ganglioneuroma, and astrocytoma in the same mass. The tumour arose in the hypothalamus of a 43 year old diabetic woman who also had alpha cell hyperplasia and beta cell hypoplasia of the islets of Langerhans. It is suggested that both hypothalamic and pancreatic lesions produced diabetes mellitus in this patient.

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Selected References

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  1. HAUSBERGER F. X., BROADHEAD C. L., Jr, HAUSBERGER B. C. OBESITY AND DIABETES MELLITUS IN A RAT WITH HYPOTHALAMIC LESIONS. CASE REPORT AND REVIEW OF LITERATURE. Acta Endocrinol (Copenh) 1964 Apr;45:600–604. doi: 10.1530/acta.0.0450600. [DOI] [PubMed] [Google Scholar]
  2. Jakumeit H. D., Zimmermann V., Guiot G. Intrasellar gangliocytomas. Report of four cases. J Neurosurg. 1974 May;40(5):626–630. doi: 10.3171/jns.1974.40.5.0626. [DOI] [PubMed] [Google Scholar]
  3. Killeffer F. A., Stern W. E. Chronic effects of hypothalamic injury. Report of a case of near total hypothalamic destruction resulting from removal of a craniopharyngioma. Arch Neurol. 1970 May;22(5):419–429. doi: 10.1001/archneur.1970.00480230037004. [DOI] [PubMed] [Google Scholar]
  4. McGavran M. H., Unger R. H., Recant L., Polk H. C., Kilo C., Levin M. E. A glucagon-secreting alpha-cell carcinoma of the pancreas. N Engl J Med. 1966 Jun 23;274(25):1408–1413. doi: 10.1056/NEJM196606232742503. [DOI] [PubMed] [Google Scholar]
  5. Moossy J., Wilson C. B. Solitary intracranial plasmacytoma. Arch Neurol. 1967 Feb;16(2):212–216. doi: 10.1001/archneur.1967.00470200100009. [DOI] [PubMed] [Google Scholar]
  6. RUSSELL D. S., RUBINSTEIN L. J. Ganglioglioma: a case with long history and malignant evolution. J Neuropathol Exp Neurol. 1962 Apr;21:185–193. [PubMed] [Google Scholar]
  7. Reeves A. G., Plum F. Hyperphagia, rage, and dementia accompanying a ventromedial hypothalamic neoplasm. Arch Neurol. 1969 Jun;20(6):616–624. doi: 10.1001/archneur.1969.00480120062005. [DOI] [PubMed] [Google Scholar]
  8. SCHOOLMAN H. M., DUBIN A., HOFFMAN W. S. Clinical syndromes associated with hypernatremia. AMA Arch Intern Med. 1955 Jan;95(1):15–23. doi: 10.1001/archinte.1955.00250070031003. [DOI] [PubMed] [Google Scholar]
  9. Shuangshoti S., Netsky M. G. Brain tumor of mixed mesenchymal and neuroepithelial origin. Case report. J Neurosurg. 1971 Jun;34(6):808–813. doi: 10.3171/jns.1971.34.6.0808. [DOI] [PubMed] [Google Scholar]
  10. Shuangshoti S., Netsky M. G. Neoplasms of mixed mesenchymal and neuroepithelial origin. Relation to "monstrocellular sarcoma" or "giant-celled glioblastoma". J Neuropathol Exp Neurol. 1971 Apr;30(2):290–309. doi: 10.1097/00005072-197104000-00010. [DOI] [PubMed] [Google Scholar]
  11. Shuangshoti S., Panyathanya R. Neural neoplasms in Thailand: a study of 2,897 cases. Neurology. 1974 Dec;24(12):1127–1134. doi: 10.1212/wnl.24.12.1127. [DOI] [PubMed] [Google Scholar]
  12. Vejjajiva A., Sitprija V., Shuangshoti S. Chronic sustained hypernatremia and hypovolemia in hypothalamic tumor. A physiologic study. Neurology. 1969 Feb;19(2):161–166. doi: 10.1212/wnl.19.2.161. [DOI] [PubMed] [Google Scholar]

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