Abstract
The distribution of activity in the dominant hemisphere was measured with the regional cerebral blood flow (rCBF) technique in 27 chronic schizophrenics and 15 non-schizophrenic control subjects (alcoholics) at rest and during phychological testing. In the non-schizophrenics, an increase of rCBF was observed during the test in frontal regions. In the chronic schizophrenics, on the other hand, no or only a very limited increase was recorded. In postcentral structures the flow response during the testing was, by and large, equal in the psychotics and the controls. The findings support the hypothesis advanced previously by the authors that in chronic schizophrenia there is defective transmission in the mediothalamic frontocortical projection bundle. This defect also appears responsible for the abnormally low resting flow (activity) in the dominant hemisphere in chronic schizophrenia which we have described previously.
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Selected References
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- Bowers M. B., Jr, Freedman D. X. "Psychedelic" experiences in acute psychoses. Arch Gen Psychiatry. 1966 Sep;15(3):240–248. doi: 10.1001/archpsyc.1966.01730150016003. [DOI] [PubMed] [Google Scholar]
- Chapman J. The early symptoms of schizophrenia. Br J Psychiatry. 1966 Mar;112(484):225–251. doi: 10.1192/bjp.112.484.225. [DOI] [PubMed] [Google Scholar]
- Ingvar D. H., Franzén G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand. 1974;50(4):425–462. doi: 10.1111/j.1600-0447.1974.tb09707.x. [DOI] [PubMed] [Google Scholar]
- Ingvar D. H., Franzén G. Distribution of cerebral activity in chronic schizophrenia. Lancet. 1974 Dec 21;2(7895):1484–1486. doi: 10.1016/s0140-6736(74)90221-9. [DOI] [PubMed] [Google Scholar]
- Lassen N. A., Ingvar D. H. Radioisotopic assessment of regional cerebral blood flow. Prog Nucl Med. 1972;1:376–409. [PubMed] [Google Scholar]
- ROCKLAND L. H., POLLIN W. QUANTIFICATION OF PSYCHIATRIC MENTAL STATUS. FOR USE WITH PSYCHOTIC PATIENTS. Arch Gen Psychiatry. 1965 Jan;12:23–28. doi: 10.1001/archpsyc.1965.01720310025004. [DOI] [PubMed] [Google Scholar]
- Risberg J., Ingvar D. H. Patterns of activation in the grey matter of the dominant hemisphere during memorizing and reasoning. A study of regional cerebral blood flow changes during psychological testing in a group of neurologically normal patients. Brain. 1973 Dec;96(4):737–756. doi: 10.1093/brain/96.4.737. [DOI] [PubMed] [Google Scholar]