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. 1976 Jan;39(1):66–76. doi: 10.1136/jnnp.39.1.66

Gliomas (astrocytomas) of the brain-stem with spinal intra- and extradural metastases: report of three cases.

J J Kepes, C M Striebinger, C E Brackett, P Kishore
PMCID: PMC492217  PMID: 1255215

Abstract

Astrocytomas of the pons and medulla oblongata ('brain-stem gliomas') while often invasive locally, do not as a rule seed and metastasize along the spinal meninges. Three cases are here reported (two adults, one child) in whom astrocytoma of the brain-stem metastasized along the spinal cord. The dura mater itself and the spinal epidural space were invaded in two cases. The child and one adult had a pontine astrocytoma, the other adult's tumour originated in the medulla oblongata. In the two cases that came to necropsy the tumour of the brain-stem was much better differentiated than the meningeal deposits. These three cases suggest that the possibility of spinal spread of brain-stem gliomas should be considered when dealing with diagnostic and therapeutic problems of such patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNETT H. J., HYLAND H. H. Tumours involving the brain-stem; a study of 90 cases arising in the brain-stem, fourth ventricle, and pineal tissue. Q J Med. 1952 Jul;21(83):265–284. [PubMed] [Google Scholar]
  2. BRAY P. F., CARTER S., TAVERAS J. M. Brainstem tumors in children. Neurology. 1958 Jan;8(1):1–7. doi: 10.1212/wnl.8.1.1. [DOI] [PubMed] [Google Scholar]
  3. COOPER I. S., KERNOHAN J. W., CRAIG W. M. Tumors of the medulla oblongata. AMA Arch Neurol Psychiatry. 1952 Mar;67(3):269–282. doi: 10.1001/archneurpsyc.1952.02320150002001. [DOI] [PubMed] [Google Scholar]
  4. Golden G. S., Ghatak N. R., Hirano A., French J. H. Malignant glioma of the brain-stem. A clinicopathological analysis of 13 cases. J Neurol Neurosurg Psychiatry. 1972 Oct;35(5):732–738. doi: 10.1136/jnnp.35.5.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lassiter K. R., Alexander E., Jr, Davis C. H., Jr, Kelly D. L., Jr Surgical treatment of brain stem gliomas. J Neurosurg. 1971 Jun;34(6):719–725. doi: 10.3171/jns.1971.34.6.0719. [DOI] [PubMed] [Google Scholar]
  6. Lassman L. P., Arjona V. E. Pontine gliomas of childhood. Lancet. 1967 Apr 29;1(7496):913–915. doi: 10.1016/s0140-6736(67)91485-7. [DOI] [PubMed] [Google Scholar]
  7. Panitch H. S., Berg B. O. Brain stem tumors of childhood and adolescence. Am J Dis Child. 1970 Jun;119(6):465–472. doi: 10.1001/archpedi.1970.02100050467001. [DOI] [PubMed] [Google Scholar]
  8. ROTH J. G., ELVIDGE A. R. Glioblastoma multiforme: a clinical survey. J Neurosurg. 1960 Jul;17:736–750. doi: 10.3171/jns.1960.17.4.0736. [DOI] [PubMed] [Google Scholar]
  9. Rubinstein L. J., Herman M. M., Hanbery J. W. The relationship between differentiating medulloblastoma and dedifferentiating diffuse cerebellar astrocytoma. Light, electron microscopic, tissue, and organ culture observations. Cancer. 1974 Mar;33(3):675–690. doi: 10.1002/1097-0142(197403)33:3<675::aid-cncr2820330312>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  10. WHITE H. H. Brain stem tumors occurring in adults. Neurology. 1963 Apr;13:292–300. doi: 10.1212/wnl.13.4.292. [DOI] [PubMed] [Google Scholar]

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