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. 1976 Mar;39(3):244–248. doi: 10.1136/jnnp.39.3.244

Altered growth hormone release in Huntington's chorea.

H J Keogh, R H Johnson, R N Nanda, W R Sulaiman
PMCID: PMC492262  PMID: 132511

Abstract

Glucose tolerance tests have been performed on five patients with Huntington's chorea and no difference in response has been observed compared with seven controls. Insulin tolerance tests have been performed on 12 patients with Huntington's chorea and 10 controls. Blood samples were taken at regular intervals for 75 minutes and analysed for blood glucose, insulin, and growth hormone (HGH). There was no difference between the groups in the hypoglycaemia which developed. The patients, however, had an earlier elevation of HGH than the controls. The difference was highly significant (P less than 0.001, P less than 0.02) 30 and 35 minutes after the intravenous injection of insulin. The patients, although awake, ceased to have choreiform movements for at least the last 60 minutes of the insulin tolerance tests. Our observations of HGH release imply that hypothalamic activity is altered in Huntington's chorea. Further observations of HGH release may therefore be of value in its diagnosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albano J. D., Ekins R. P., Maritz G., Turner R. C. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol (Copenh) 1972 Jul;70(3):487–509. doi: 10.1530/acta.0.0700487. [DOI] [PubMed] [Google Scholar]
  2. BARBEAU A. Dopamine and basal ganglia diseases. Arch Neurol. 1961 Jan;4:97–102. doi: 10.1001/archneur.1961.00450070099011. [DOI] [PubMed] [Google Scholar]
  3. Boyd A. E., 3rd, Lebovitz H. E., Pfeiffer J. B. Stimulation of human-growth-hormone secretion by L-dopa. N Engl J Med. 1970 Dec 24;283(26):1425–1429. doi: 10.1056/NEJM197012242832602. [DOI] [PubMed] [Google Scholar]
  4. EHRINGER H., HORNYKIEWICZ O. [Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system]. Klin Wochenschr. 1960 Dec 15;38:1236–1239. doi: 10.1007/BF01485901. [DOI] [PubMed] [Google Scholar]
  5. FORREST A. D. Some observations on Huntington's chorea. J Ment Sci. 1957 Jul;103(432):507–513. doi: 10.1192/bjp.103.432.507. [DOI] [PubMed] [Google Scholar]
  6. Kansal P. C., Buse J., Talbert O. R., Buse M. G. The effect of L-dopa on plasma growth hormone, insulin, and thyroxine. J Clin Endocrinol Metab. 1972 Jan;34(1):99–105. doi: 10.1210/jcem-34-1-99. [DOI] [PubMed] [Google Scholar]
  7. Klawans H. L., Jr A pharmacologic analysis of Huntington's chorea. Eur Neurol. 1970;4(3):148–163. doi: 10.1159/000114017. [DOI] [PubMed] [Google Scholar]
  8. Klawans H. L., Jr Cerebrospinal fluid homovanillic acid in Huntington's chorea. J Neurol Sci. 1971 Jul;13(3):277–279. doi: 10.1016/0022-510x(71)90032-3. [DOI] [PubMed] [Google Scholar]
  9. Klawans H. L., Jr, Paulson G. W., Ringel S. P., Barbeau A. Use of L-dopa in the detection of presymptomatic Huntington's chorea. N Engl J Med. 1972 Jun 22;286(25):1332–1334. doi: 10.1056/NEJM197206222862503. [DOI] [PubMed] [Google Scholar]
  10. MANN L. B., WEBER A. B. Control of post-pneumoencephalographic headaches with EC 112; a preliminary review. Bull Los Angel Neuro Soc. 1953 Mar;18(1):52–54. [PubMed] [Google Scholar]
  11. McLellan D. L., Chalmers R. J., Johnson R. H. A double-blind trial of tetrabenazine, thiopropazate, and placebo in patients with chorea. Lancet. 1974 Jan 26;1(7848):104–107. doi: 10.1016/s0140-6736(74)92338-1. [DOI] [PubMed] [Google Scholar]
  12. Podolsky S., Leopold N. A. Biogenic amines in the hypothalamus: effect of L-DOPA on human growth hormone levels in patients with Huntington's chorea. Prog Brain Res. 1973;39:225–235. doi: 10.1016/S0079-6123(08)64080-7. [DOI] [PubMed] [Google Scholar]
  13. Podolsky S., Leopold N. A., Sax D. S. Increased frequency of diabetes mellitus in patients with Huntington's chorea. Lancet. 1972 Jun 24;1(7765):1356–1358. doi: 10.1016/s0140-6736(72)91092-6. [DOI] [PubMed] [Google Scholar]
  14. ROTH J., GLICK S. M., YALOW R. S., BERSONSA Hypoglycemia: a potent stimulus to secretion of growth hormone. Science. 1963 May 31;140(3570):987–988. doi: 10.1126/science.140.3570.987. [DOI] [PubMed] [Google Scholar]

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