Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1976 Apr;39(4):341–349. doi: 10.1136/jnnp.39.4.341

Uptake of bleomycin by human brain tumours 1

T Hayakawa 1,2,2, Y Ushio 1,2, K Morimoto 1,2, H Hasegawa 1,2, H Mogami 1,2, K Horibata 1,2
PMCID: PMC492283  PMID: 58971

Abstract

The uptake of bleomycin (BLM) by various types of brain tumours after intravenous or intrathecal administration was investigated by bioassay in 67 patients. The correlation between the BLM distribution and the type and characteristics of brain tumours was studied.

Full text

PDF
341

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Graul E. H., Schaumlöffel E., Hundeshagen H., Wilmanns H., Simon G. Metabolism of radioactive cyclophosphamide. Animal tests and clinical studies. Cancer. 1967 May;20(5):896–899. doi: 10.1002/1097-0142(1967)20:5<896::aid-cncr2820200551>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  2. Hayakawa T., Ushio Y., Mogami H., Horibata K. The uptake, distribution and anti-tumor activity of bleomycin in gliomas in the mouse. Eur J Cancer. 1974 Mar;10(3):137–142. doi: 10.1016/0014-2964(74)90145-5. [DOI] [PubMed] [Google Scholar]
  3. Hayakawa T., Yamada R., Kanai N., Kuroda R., Higashi H. Experimental studies on the chemotherapy of brain tumors. 2. Localization of cytostatic agents in central nervous tissue after intravenous, intracarotid and intrathecal administration. Med J Osaka Univ. 1968 Mar;18(4):389–395. [PubMed] [Google Scholar]
  4. Ichikawa T., Matsuda A., Miyamoto K., Tsubosaki M., Umezawa H. Biological studies on bleomycin A. J Antibiot (Tokyo) 1967 Jul;20(3):149–155. [PubMed] [Google Scholar]
  5. MAHALEY M. S., Jr, HUNEYCUTT H., BOONE S., WOODHALL B. Localization of methyl-bis(2-chloroethyl-1,2-C14)amine hydrochloride in nervous tissue after intravenous injection or regional cerebral perfusion in dogs. Cancer Chemother Rep. 1961 Apr;11:29–32. [PubMed] [Google Scholar]
  6. MAHALEY M. S., Jr, WOODHALL B. The effect of anticancer agents on nervous tissue. Cancer Chemother Rep. 1962 Feb;16:543–544. [PubMed] [Google Scholar]
  7. Mamo L., Nouel J. P., Robert J., Chai N., Houdart R. Use of radioactive bleomycin to detect malignant intracranial tumors. Comparative study with technetium-99m in 104 cases. J Neurosurg. 1973 Dec;39(6):735–741. doi: 10.3171/jns.1973.39.6.0735. [DOI] [PubMed] [Google Scholar]
  8. Takeuchi K., Atsuji M., Masui T., Sueyoshi S., Hara M. [Chemotherapy of brain tumors; effect of bleomycin]. No To Shinkei. 1972 Apr;24(4):437–444. [PubMed] [Google Scholar]
  9. Umezawa H., Ishizaka M., Kimura K., Iwanaga J., Takeuchi T. Biological studies on individual bleomycins. J Antibiot (Tokyo) 1968 Oct;21(10):592–602. doi: 10.7164/antibiotics.21.592. [DOI] [PubMed] [Google Scholar]
  10. Umezawa H., Ishizuka M., Maeda K., Takeuchi T. Studies on bleomycin. Cancer. 1967 May;20(5):891–895. doi: 10.1002/1097-0142(1967)20:5<891::aid-cncr2820200550>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  11. Umezawa H., Ishizuki M., Hori S., Chimura H., Takeuchi T. The distribution of 3H-bleomycin in mouse tissue. J Antibiot (Tokyo) 1968 Nov;21(11):638–642. doi: 10.7164/antibiotics.21.638. [DOI] [PubMed] [Google Scholar]
  12. Ushio Y., Hayakawa T., Mogami H. Uptake of tritiated methotrexate by mouse brain tumors after intravenous or intrathecal administration. J Neurosurg. 1974 Jun;40(6):706–716. doi: 10.3171/jns.1974.40.6.0706. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES