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. 2011 Jul 21;61(1):95. doi: 10.1016/S0377-1237(05)80143-1

The Revaccination of Ty 21a

H Sethi *, G Keshavamurthy +
PMCID: PMC4923344  PMID: 27407716

Dear Editor,

The review article titled “Current trends in the Management of Typhoid Fever” by SP Kalra et al is very informative and educative [1]. A few aspects, however are submitted for clarification/advice.

  • (a)

    The revaccination of Ty 21a is mentioned as 5 years in Table 3. However an update article “Vaccines-what's new?” in MJAFI[2], the manufacturer's instruction and certain other authors [3, 4], recommend revaccination at 3 years. Secondly, dosage mentioned is one capsule every other day and a total of three capsules. However a review article in N Eng J Med “Typhoid Fever” [5] mentions dosage to be one capsule on days 1,3,5 and 7 (total four capsules).

  • (b)
    The dosage : mg/kg/day of Fluroquinolones in Table 1 is mentioned NA. However the following dosages are being followed in children [4, 6].
    • Ciprofloxacin 5-10 mg/kg/day in two divided doses.
    • Norfloxacin 7.5-15 mg/kg/day in two divided doses.
    • Ofloxacin 10-15 mg/kg/day in two divided doses.

The authors are requested to advice.

References

  • 1.Kalra SP. Current Trends in the Management of Typhoid Fever. MJAFI. 2003;59(2):130–135. doi: 10.1016/S0377-1237(03)80060-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Wilson CG, Prasad PL, Nagendra K. Vaccines — What's new? MJAFI. 2001;57(3):221–225. doi: 10.1016/S0377-1237(01)80048-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Park K. Typhoid fever. In: Park K, editor. Park's Textbook of Preventive and Social medicine. 17th ed. Banarsidass Bhanot Publishers; Jabalpur: 2002. pp. 178–181. [Google Scholar]
  • 4.Nicholson JF, Michael AP. Laboratory Medicine and Reference tables. In: Behrman RE, Kleogman RM, Jenson HB, editors. Nelson Textbook of Pediatrics. 16th ed. WB Saunders Co.; Philadelphia: 2000. pp. 2031–2084. [Google Scholar]
  • 5.Christopher MP. Typhoid Fever. N Eng J Med. 2002;347(22):1770–1782. doi: 10.1056/NEJMra020201. [DOI] [PubMed] [Google Scholar]
  • 6.Singh M, Deorari AK. Antibiotics and chemotherapeutic agents. In: Singh M, Deorari AK, editors. Drug dosages in children. 4th ed. Sagar Publications; 1997. pp. 21–32. [Google Scholar]

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