Table 8. Cox proportional hazard models of COMT rs4680 and rs4633 effects on type 2 diabetes by treatment arm in the DPP stratified by race.

	Placebo (n = 909)				Metformin (n = 896)				Lifestyle (n = 909)
All ethnicities	HR	Conf. limits		P val	HR	Conf. limits		P val	HR	Conf. limits		P val
Rs4633	1.02	0.84	1.23	0.85	0.76	0.60	0.97	0.03	1.09	0.84	1.41	0.53
Rs4680	0.99	0.82	1.18	0.88	0.81	0.65	1	0.05	1.04	0.82	1.33	0.73
Caucasians	n = 499				n = 512				n = 492
Rs4633	1.11	0.85	1.45	0.43	0.85	0.61	1.24	0.37	1.04	0.74	1.47	0.82
Rs4680	1.22	0.95	1.56	0.12	0.87	0.65	1.16	0.35	0.97	0.71	1.32	0.84
African American	n = 192				n = 184				n = 178
Rs4633	1.08	0.70	1.64	0.74	0.55	0.33	0.94	0.03	1.11	0.63	1.96	0.71
Rs4680	0.79	0.55	1.15	0.22	0.68	0.43	1.07	0.10	1.44	0.78	2.65	0.25
Hispanic	n = 152				n = 145				n = 162
Rs4633	1.05	0.65	1.69	0.84	0.84	0.48	1.49	0.56	0.99	0.52	1.85	0.97
Rs4680	0.937	0.61	1.44	0.77	0.823	0.49	1.37	0.46	0.84	0.46	1.53	0.57
Asian/Pac Is	n = 38				n = 33				n = 49
Rs4633	0.50	0.22	1.16	0.11	1.23	0.38	0.4	0.73	2.37	0.09	50.0	0.61
Rs4680	0.48	0.21	1.08	0.08	1.02	0.37	2.83	0.97	0.53	0.12	2.33	0.40
American Indians	n = 28				n = 22				n = 28
Rs4633	0.65	0.21	2.00	0.46	0.35	0.07	1.82	0.21	NA
Rs4680	0.52	0.17	1.55	0.24	0.52	0.13	2.06	0.35	NA