Figure 2. Phenotypic alterations in CAR⁺/mPSCs^Oct-4_hi.

A. Altered cell cycle distribution. The population for G₁-, S-, and G₂/M-phases of cell cycle were analyzed of CAR⁺/mPSCs and CAR⁺/mPSCs^Oct-4_hi C1, E9, and C7 clones. Data are presented as mean ± SD. Both the S- and G₂/M-phase population of CAR⁺/mPSCs^Oct-4_hi clones were strongly increased, ** P < 0.01 compared with CAR⁺/mPSCs. B. Telomerase activity in CAR⁺/mPSCs and CAR⁺/mPSCs^Oct-4_hi clones. C1, E9, and C7 clones were evaluated in the 12^th, 20^th, and 50^th passages. CAR⁺ denotes CAR⁺/mPSCs. H denotes heat inactivation.