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. 2016 Feb 16;7(12):14188–14198. doi: 10.18632/oncotarget.7420

Figure 3. DEPTOR inhibits proliferation, migration and invasion of ESCC cells.

Figure 3

KYSE-150 cells were transfected with plasmid to generate stable DEPTOR overexpression cell line (pcDNA3.1-DEPTOR), while KYSE-510 cells were treated with CRISR/Cas9 system to generate DEPTOR knockout cell line (CRISPR-DEPTOR). Overexpression of DEPTOR led to reduced proliferation rate (A), migration (C and G left panel) and invasive (E and G right panel) abilities, while knockout of DEPTOR caused enhanced proliferation rate (B), migration (D and H left panel) and invasive (F and H right panel) abilities in ESCC cells. Data presented as Mean ± SD, n = 3 independent experiments. **p < 0.01.