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. 2016 Feb 13;7(12):14324–14335. doi: 10.18632/oncotarget.7365

Figure 3. LED vs Laser NIR-PIT in in vitro 3D spheroids.

Figure 3

(A) A431 3D spheroids treated with NIR-PIT mediated by LED or Laser were observed by microscopy (before and after irradiation of NIR-light). Necrotic cell damage was observed after NIR-PIT. Bar = 100 μm. (B) LDH cytotoxicity assay (for the spheroids treated with NIR-PIT mediated by LED or Laser) showed increasing cell death with increases in light dose. Significant differences in efficacy were demonstrated between LED and Laser (n = 5; *P < 0.05, **P < 0.01).