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. 2016 Feb 11;7(12):14350–14365. doi: 10.18632/oncotarget.7320

Figure 3. LDE225 inhibits actin polymerization in MCL cells.

Figure 3

A. MCL cells were treated with LDE225 (10 μM or 30 μM) or LDE225 (30 μM) in combination with rhSDF-1 (100 ng/ml) or rhIL-6 (50 ng/ml), and actin polymerization was measured using FITC-phalloidin. Cells treated with rhSDF-1 (100 ng/ml) alone, rhIL-6 (50 ng/ml) alone or DMSO were used as controls. Intracellular F-actin content was determined using FACS analyses. The representative MFI ratio in each sample was indicated. B. The relative F-actin content in each treated cell is displayed as the mean ± S.D. from three independent experiments. *p < 0.05, **p < 0.01 (the mean of LDE225-treated cells vs. the mean of DMSO-treated cells from three cell lines and two patient samples; Student's t-test).