Abstract
The red cell 2,3 DPG, the most important factor for oxygen delivery in the tissues, was found to be increased in Parkinsonism patients compared with controls. The aging process seems not to be a factor in the increased 2,3 DPG concentration. Other factors relevant to raised 2,3 DPG level such as physical activity, increased oxygen requirements, and metabolic changes are discussed.
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Selected References
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- Askari A., Rao S. N. Regulation of AMP deaminase by 2,3-diphosphoglyceric acid: a possible mechanism for the control of adenine nucleotide metabolism in human erythrocytes. Biochim Biophys Acta. 1968 Jan 8;151(1):198–203. doi: 10.1016/0005-2744(68)90174-5. [DOI] [PubMed] [Google Scholar]
- BARTLETT G. R. Colorimetric assay methods for free and phosphorylated glyceric acids. J Biol Chem. 1959 Mar;234(3):469–471. [PubMed] [Google Scholar]
- Barbeau A., Campanella G., Butterworth R. F., Yamada K. Uptake and efflux of 14-C-dopamine in platelets: evidence for a generalized defect in Parkinson's disease. Neurology. 1975 Jan;25(1):1–9. doi: 10.1212/wnl.25.1.1. [DOI] [PubMed] [Google Scholar]
- Bellingham A. J., Detter J. C., Lenfant C. Regulatory mechanisms of hemoglobin oxygen affinity in acidosis and alkalosis. J Clin Invest. 1971 Mar;50(3):700–706. doi: 10.1172/JCI106540. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bunn H. F., Ransil B. J., Chao A. The interaction between erythrocyte organic phosphates, magnesium ion, and hemoglobin. J Biol Chem. 1971 Sep 10;246(17):5273–5279. [PubMed] [Google Scholar]
- Cavagnini F., Peracchi M., Scotti G., Raggi U., Pontiroli A. E., Bana R. Effect of L-dopa administration on growth hormone secretion in normal subjects and Parkinsonian patients. J Endocrinol. 1972 Sep;54(3):425–433. doi: 10.1677/joe.0.0540425. [DOI] [PubMed] [Google Scholar]
- Durell J., Garland J. T., Friedel R. O. Acetylcholine action: biochemical aspects. Science. 1969 Aug 29;165(3896):862–866. doi: 10.1126/science.165.3896.862. [DOI] [PubMed] [Google Scholar]
- EGGER E., RAPOPORT S. ROLE OF NON-COVALENT BONDS FOR THE HOLDING, ACTIVATION AND RELEASE OF MITOCHONDRIAL ENZYMES. Nature. 1963 Oct 19;200:240–242. doi: 10.1038/200240a0. [DOI] [PubMed] [Google Scholar]
- Eaton J. W., Brewer G. J., Grover R. F. Role of red cell 2,3-diphosphoglycerate in the adaptation of man to altitude. J Lab Clin Med. 1969 Apr;73(4):603–609. [PubMed] [Google Scholar]
- Eaton J. W., Brewer G. J. The relationship between red cell 2,3-diphosphoglycerate and levels of hemoglobin in the human. Proc Natl Acad Sci U S A. 1968 Oct;61(2):756–760. doi: 10.1073/pnas.61.2.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eaton J. W., Faulkner J. A., Brewer G. J. Response of the human red cell to muscular activity. Proc Soc Exp Biol Med. 1969 Dec;132(3):886–887. doi: 10.3181/00379727-132-34329. [DOI] [PubMed] [Google Scholar]
- GREIG M. E., GIBBONS A. J. Possible mechanism of action by which phenothiazine derivatives preserve stored blood. Am J Physiol. 1955 May;181(2):313–318. doi: 10.1152/ajplegacy.1955.181.2.313. [DOI] [PubMed] [Google Scholar]
- Geel S. E., Timiras P. S. Influence of neonatal hypothyroidism and of thyroxine on the acetylcholinesterase and cholinesterase activities in the developing central nervous system of the rat. Endocrinology. 1967 Jun;80(6):1069–1074. doi: 10.1210/endo-80-6-1069. [DOI] [PubMed] [Google Scholar]
- Gorshein D., Oski F. A., Delivoria-Papadopoulos M. Effect of androgens on the red cell 2, 3 diphosphoglycerate hemoglobin oxygen affinity and red cell mass in mammals. Proc Soc Exp Biol Med. 1974 Dec;147(3):616–618. doi: 10.3181/00379727-147-38400. [DOI] [PubMed] [Google Scholar]
- Grosz H. J., Farmer B. B. Reduction-oxidation potential of blood determined by oxygen releasing factor in thyroid disorders. Nature. 1969 May 31;222(5196):875–876. doi: 10.1038/222875a0. [DOI] [PubMed] [Google Scholar]
- Håkanson R., Lundquist I., Rerup C. On the hyperglycaemic effect of DOPA and dopamine. Eur J Pharmacol. 1967 Mar;1(2):114–119. doi: 10.1016/0014-2999(67)90047-7. [DOI] [PubMed] [Google Scholar]
- Klawans H. L., Jr The pharmacology of parkinsonism (a review). Dis Nerv Syst. 1968 Dec;29(12):805–816. [PubMed] [Google Scholar]
- Lenfant C., Torrance J., English E., Finch C. A., Reynafarje C., Ramos J., Faura J. Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels. J Clin Invest. 1968 Dec;47(12):2652–2656. doi: 10.1172/JCI105948. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lipman I. J., Boykin M. E., Flora R. E. Glucose intolerance in Parkinson's disease. J Chronic Dis. 1974 Dec;27(11-12):573–579. doi: 10.1016/0021-9681(74)90031-9. [DOI] [PubMed] [Google Scholar]
- Mier M. Mechanisms leading to hypoventilation in extrapyramidal disorders, with special reference to Parkinson's disease. J Am Geriatr Soc. 1967 Mar;15(3):230–238. doi: 10.1111/j.1532-5415.1967.tb01132.x. [DOI] [PubMed] [Google Scholar]
- Miller L. D., Oski F. A., Diaco J. F., Sugerman H. J., Gottlieb A. J., Davidson D., Delivoria-Papadopoulos M. The affinity of hemoglobin for oxygen: its control and in vivo significance. Surgery. 1970 Jul;68(1):187–195. [PubMed] [Google Scholar]
- Miller W. W., Delivoria-Papadopoulos M., Miller L., Oski F. A. Oxygen releasing factor in hyperthyroidism. JAMA. 1970 Mar 16;211(11):1824–1826. [PubMed] [Google Scholar]
- Oski F. A., Gottlieb A. J., Delivoria-Papadopoulos M., Miller W. W. Red-cell 2,3-diphosphoglycerate levels in subjects with chronic hypoxemia. N Engl J Med. 1969 May 22;280(21):1165–1166. doi: 10.1056/NEJM196905222802108. [DOI] [PubMed] [Google Scholar]
- Paulson G. D., Tafrate R. H. Some "minor" aspects of parkinsonism, especially pulmonary function. Neurology. 1970 Dec;20(12):14–17. [PubMed] [Google Scholar]
- Rose Z. B. The purification and properties of diphosphoglycerate mutase from human erythrocytes. J Biol Chem. 1968 Sep 25;243(18):4810–4820. [PubMed] [Google Scholar]
- Snyder L. M., Reddy W. J. Mechanism of action of thyroid hormones on erythrocyte 2,3-diphosphoglyceric acid synthesis. J Clin Invest. 1970 Nov;49(11):1993–1998. doi: 10.1172/JCI106419. [DOI] [PMC free article] [PubMed] [Google Scholar]
