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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1976 Oct;39(10):995–1000. doi: 10.1136/jnnp.39.10.995

Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin

Pamela M Le Quesne 1,2,3,4, Valerie Goldberg 1,2,3,4, F Vajda 1,2,3,4
PMCID: PMC492503  PMID: 1003245

Abstract

Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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