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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1976 Dec;39(12):1145–1150. doi: 10.1136/jnnp.39.12.1145

Congenital myasthenia gravis: clinical and HLA studies in two brothers.

A M Whiteley, M S Schwartz, J A Sachs, M Swash
PMCID: PMC492558  PMID: 1011024

Abstract

Two brothers with congenital myasthenia gravis are described. In both, ptosis and ophthalmoplegia responded poorly to oral anticholinesterase therapy and to thymectomy. The brothers had two different HLA haplotypes and neither had the HLA-A1-B8-DW3 haplotypes which are commonly associated with myathenia gravis in adult-onset cases.

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Selected References

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