Abstract
Results of a cytophotometric study have shown a widespread reduction in cytoplasmic RNA of nerve cells. It appears, therefore, that although certain aspects of the symptomatology of senile dementia may be accounted for by lesions in particular anatomical sites, the main part of the neurological disturbance is related to more broadly based changes in nerve cell metabolism affecting much, if not all, of the CNS.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Colon E. J. The cerebral cortex in presenile dementia. A quantitative analysis. Acta Neuropathol. 1973;23(4):281–290. doi: 10.1007/BF00687457. [DOI] [PubMed] [Google Scholar]
- Crapper D. R., Krishnan S. S., Dalton A. J. Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration. Science. 1973 May 4;180(4085):511–513. doi: 10.1126/science.180.4085.511. [DOI] [PubMed] [Google Scholar]
- Dayan A. D. Quantitative histological studies on the aged human brain. II. Senile plaques and neurofibrillary tangles in senile dementia (with an appendix on their occurrence in cases of carcinoma). Acta Neuropathol. 1970;16(2):95–102. doi: 10.1007/BF00687664. [DOI] [PubMed] [Google Scholar]
- Fisher R. H. The urinary excretion of homovanillic acid and 4-hydroxy 3-methoxy mandelic acid in the elderly demented: a preliminary communication. Gerontol Clin (Basel) 1972;14(3):172–175. doi: 10.1159/000245389. [DOI] [PubMed] [Google Scholar]
- Gedye J. L., Exton-Smith A. N., Wedgwood J. A method for measuring mental performance in the elderly and its use in a pilot clinical trial of meclofenoxate in organic dementia (preliminary communication). Age Ageing. 1972 May;1(2):74–80. doi: 10.1093/ageing/1.2.74. [DOI] [PubMed] [Google Scholar]
- Gibson P. H., Stones M., Tomlinson B. E. Senile changes in the human neocortex and hippocampus compared by the use of the electron and light microscopes. J Neurol Sci. 1976 Mar;27(3):389–405. doi: 10.1016/0022-510x(76)90011-3. [DOI] [PubMed] [Google Scholar]
- Gottfries C. G., Gottfries I., Roos B. E. Homovanillic acid and 5-hydroxyindoleacetic acid in the cerebrospinal fluid of patients with senile dementia, presenile dementia and parkinsonism. J Neurochem. 1969 Sep;16(9):1341–1345. doi: 10.1111/j.1471-4159.1969.tb05984.x. [DOI] [PubMed] [Google Scholar]
- Gottfries C. G., Kjällquist A., Pontén U., Roos B. E., Sundbärg G. Cerebrospinal fluid pH and monoamine and glucolytic metabolites in Alzheimer's disease. Br J Psychiatry. 1974 Mar;124(0):280–287. doi: 10.1192/bjp.124.3.280. [DOI] [PubMed] [Google Scholar]
- KLATZO I., WISNIEWSKI H., STREICHER E. EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS. J Neuropathol Exp Neurol. 1965 Apr;24:187–199. doi: 10.1097/00005072-196504000-00002. [DOI] [PubMed] [Google Scholar]
- Kobayashi R. M., Palkovits M., Kopin I. J., Jacobowitz D. M. Biochemical mapping of noradrenergic nerves arising from the rat locus coeruleus. Brain Res. 1974 Sep 6;77(2):269–279. doi: 10.1016/0006-8993(74)90790-2. [DOI] [PubMed] [Google Scholar]
- Mann D. M., Yates P. O. Lipoprotein pigments--their relationship to ageing in the human nervous system. I. The lipofuscin content of nerve cells. Brain. 1974 Sep;97(3):481–488. doi: 10.1093/brain/97.1.481. [DOI] [PubMed] [Google Scholar]
- Mehraein P., Yamada M., Tarnowska-Dziduszko E. Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia. Adv Neurol. 1975;12:453–458. [PubMed] [Google Scholar]
- Miller E. Short- and long-term memory in patients with presenile dementia (Alzheimer's disease). Psychol Med. 1973 May;3(2):221–224. doi: 10.1017/s003329170004856x. [DOI] [PubMed] [Google Scholar]
- Nandy K. Further studies on the effects of centrophenoxine on the lipofuscin pigment in the neurons of senile guinea pigs. J Gerontol. 1968 Jan;23(1):82–92. doi: 10.1093/geronj/23.1.82. [DOI] [PubMed] [Google Scholar]
- Nikaido T., Austin J., Trueb L., Rinehart R. Studies in ageing of the brain. II. Microchemical analyses of the nervous system in Alzheimer patients. Arch Neurol. 1972 Dec;27(6):549–554. doi: 10.1001/archneur.1972.00490180085017. [DOI] [PubMed] [Google Scholar]
- Olson L., Fuxe K. On the projections from the locus coeruleus noradrealine neurons: the cerebellar innervation. Brain Res. 1971 Apr 16;28(1):165–171. doi: 10.1016/0006-8993(71)90533-6. [DOI] [PubMed] [Google Scholar]
- Shea J. R., Jr A method for in situ cytophotometric estimation of absolute amount of ribonucleic acid using azure B1. J Histochem Cytochem. 1970 Feb;18(2):143–152. doi: 10.1177/18.2.143. [DOI] [PubMed] [Google Scholar]
- Spoerri P. E., Glees P. The mode of lipofuscin removal from hypothalamic neurons. Exp Gerontol. 1975 Aug;10(3-4):225–228. doi: 10.1016/0531-5565(75)90035-2. [DOI] [PubMed] [Google Scholar]
- Tomlinson B. E., Blessed G., Roth M. Observations on the brains of demented old people. J Neurol Sci. 1970 Sep;11(3):205–242. doi: 10.1016/0022-510x(70)90063-8. [DOI] [PubMed] [Google Scholar]
- Tomlinson B. E., Kitchener D. Granulovacuolar degeneration of hippocampal pyramidal cells. J Pathol. 1972 Mar;106(3):165–185. doi: 10.1002/path.1711060305. [DOI] [PubMed] [Google Scholar]
- Ungerstedt U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl. 1971;367:1–48. doi: 10.1111/j.1365-201x.1971.tb10998.x. [DOI] [PubMed] [Google Scholar]
- VICTOR M., ANGEVINE J. B., Jr, MANCALL E. L., FISHER C. M. [Memory loss with lesions of hippocampal formation. Report of a case with some remarks on the anatomical basis of memory]. Arch Neurol. 1961 Sep;5:244–263. doi: 10.1001/archneur.1961.00450150010002. [DOI] [PubMed] [Google Scholar]
- Watson W. E. Observations on the nucleolar and total cell body nucleic acid of injured nerve cells. J Physiol. 1968 Jun;196(3):655–676. doi: 10.1113/jphysiol.1968.sp008528. [DOI] [PMC free article] [PubMed] [Google Scholar]