Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1977 Jul;40(7):702–707. doi: 10.1136/jnnp.40.7.702

Sarcoid-like disorder of the intracranial optic nerve

Clinicopathological report of two cases

L Frisén 1,2,3,4, S Lindgren 1,2,3,4, B J L MacGregor 1,2,3,4, S Stattin 1,2,3,4
PMCID: PMC492808  PMID: 199708

Abstract

Two cases with a sarcoid-like disorder apparently restricted to the intracranial optic nerve and the adjacent dura mater are described, doublilng the number of reported cases. In both instances there were unilateral visual loss and unusual radiographic changes in the optic canal area. Biopsy samples showed localised infiltration of tissues with non-caseating tubercles containing epithelioid and multinucleated giant cells.

Full text

PDF

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALAJOUANINE T., FEREY D., HOUDART R., ARDOUIN M. Forme neuro-oculaire pure de la maladie de Besnier-Boeck-Schaumann; amblyopie rapide par atteinte successive des deux nerfs optiques a un an de distance. Rev Neurol (Paris) 1952;86(3):255–257. [PubMed] [Google Scholar]
  2. ASZKANAZY C. L. Sarcoidosis of the central nervous system. J Neuropathol Exp Neurol. 1952 Oct;11(4):392–400. doi: 10.1097/00005072-195210000-00003. [DOI] [PubMed] [Google Scholar]
  3. Anderson W. B., Parker J. J., Sondheimer F. K. Optic foramen enlargement caused by sarcoid granuloma. Radiology. 1966 Feb;86(2):319–322. doi: 10.1148/86.2.319. [DOI] [PubMed] [Google Scholar]
  4. Blain J. G., Riley W., Logothetis J. Optic nerve manifestations of sarcoidosis. Arch Neurol. 1965 Sep;13(3):307–309. doi: 10.1001/archneur.1965.00470030087008. [DOI] [PubMed] [Google Scholar]
  5. Douglas A. C., Maloney A. F. Sarcoidosis of the central nervous system. J Neurol Neurosurg Psychiatry. 1973 Dec;36(6):1024–1033. doi: 10.1136/jnnp.36.6.1024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Drury R. A. Problems in histological interpretation in sarcoidosis. Postgrad Med J. 1970 Aug;46(538):478–483. doi: 10.1136/pgmj.46.538.478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HOOK O. Sarcoidosis with involvement of the nervous system; report of nine cases. AMA Arch Neurol Psychiatry. 1954 May;71(5):554–575. [PubMed] [Google Scholar]
  8. Hasso A. N., Bentson J. R., Wilson G. H., Vignaud J. Neuroradiology of the sphenoidal region. Radiology. 1975 Mar;114(3):619–627. doi: 10.1148/114.3.619. [DOI] [PubMed] [Google Scholar]
  9. Herring A. B., Urich H. Sarcoidosis of the central nervous system. J Neurol Sci. 1969 Nov-Dec;9(3):405–422. doi: 10.1016/0022-510x(69)90086-0. [DOI] [PubMed] [Google Scholar]
  10. Ingestad R., Stigmar G. Sarcoidosis with ocular and hypothalamic-pituitary manifestations. Acta Ophthalmol (Copenh) 1971;49(1):1–10. doi: 10.1111/j.1755-3768.1971.tb08227.x. [DOI] [PubMed] [Google Scholar]
  11. Jampol L. M., Woodfin W., McLean E. B. Optic nerve sarcoidosis. Report of a case. Arch Ophthalmol. 1972 Mar;87(3):355–360. doi: 10.1001/archopht.1972.01000020357023. [DOI] [PubMed] [Google Scholar]
  12. Laties A. M., Scheif H. G. Evolution of multiple small tumors in sarcoid granuloma of the optic disk. Am J Ophthalmol. 1972 Jul;74(1):60–67. doi: 10.1016/0002-9394(72)91126-9. [DOI] [PubMed] [Google Scholar]
  13. Lee K. F. The diagnostic value of hyperostosis in midline subfrontal meningioma. Radiology. 1976 Apr;119(1):121–130. doi: 10.1148/119.1.121. [DOI] [PubMed] [Google Scholar]
  14. Lee K. F., Whiteley W. H., 3rd, Schatz N. J., Edeiken J., Lin S. R., Tsai F. Y. Juxtasellar hyperostosis of non-meningiomatous origin. J Neurosurg. 1976 May;44(5):571–579. doi: 10.3171/jns.1976.44.5.0571. [DOI] [PubMed] [Google Scholar]
  15. MEYER J. S., FOLEY J. M., CAMPAGNA-PINTO D. Granulomatous angiitis of the meninges in sarcoidosis. AMA Arch Neurol Psychiatry. 1953 May;69(5):587–600. doi: 10.1001/archneurpsyc.1953.02320290039005. [DOI] [PubMed] [Google Scholar]
  16. MORAX P. V. Les localisations neuro-oculaires de la réticulo-endothéliose de Besnier-Boeck-Schaumann. Ann Ocul (Paris) 1956 Jan;189(1):73–91. [PubMed] [Google Scholar]
  17. Nurick S., Blackwood W., Mair W. G. Giant cell granulomatous angiitis of the central nervous system. Brain. 1972;95(1):133–142. doi: 10.1093/brain/95.1.133. [DOI] [PubMed] [Google Scholar]
  18. STATTON R., BLODI F. C., HANIGAN J. SARCOIDOSIS OF THE OPTIC NERVE. Arch Ophthalmol. 1964 Jun;71:834–836. doi: 10.1001/archopht.1964.00970010850011. [DOI] [PubMed] [Google Scholar]
  19. Scadding J. G. The definition of sarcoidosis. Postgrad Med J. 1970 Aug;46(538):465–467. doi: 10.1136/pgmj.46.538.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Scott T. V., Schatz N. J., Lee F. Malignant pituitary adenoma. A cause of sphenoid hyperostosis and monocular blindness. Arch Ophthalmol. 1974 Feb;91(2):123–125. doi: 10.1001/archopht.1974.03900060129008. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES