Abstract
The concentrations of homovanillic acid (HVA), 5-hydroxyindolylacetic acid (5-HIAA), and 4-hydroxy, 3-methoxyphenylethylene glycol (MHPG) were estimated in the lumbar cerebrospinal fluid (CSF) of control subjects and in some patients who probably, and others who definitely, suffered from multiple sclerosis (MS). In the control group, the concentration of HVA was lower in people who underwent lumbar puncture having fasted and been recumbent for 12 hours before the procedure than in those from whom CSF was obtained under non-standardised conditions. These studies demonstrate that a standardised procedure for lumbar puncture is required in order to obtain meaningful results. In patients suffering from MS the CSF 5-HIAA concentrations were significantly lower than in comparable controls but the HVA concentrations did not differ. There was no relationship between metabolite concentrations, site of lesion, the duration of the disease, gamma-globulin levels nor the occurrence of relapse within the previous month.
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Selected References
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- Claveria L. E., Curzon G., Harrison M. J., Kantamaneni B. D. Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis. J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):715–718. doi: 10.1136/jnnp.37.6.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Garelis E., Young S. N., Lal S., Sourkes T. L. Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies. Brain Res. 1974 Oct 11;79(1):1–8. doi: 10.1016/0006-8993(74)90562-9. [DOI] [PubMed] [Google Scholar]
- Johannsson B., Roos B. E. 5-Hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid of patients with neurological diseases. Eur Neurol. 1974;11(1):37–45. doi: 10.1159/000114304. [DOI] [PubMed] [Google Scholar]
- O'Keeffe R., Brooksbank B. W. Determination of 3-methoxy-4-hydroxyphenylethylene glycol, a noradrenaline metabolite, in cerebrospinal fluid and urine. Clin Chem. 1973 Sep;19(9):1031–1035. [PubMed] [Google Scholar]
- Post R. M., Kotin J., Goodwin F. K., Gordon E. K. Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness. Am J Psychiatry. 1973 Jan;130(1):67–72. doi: 10.1176/ajp.130.1.67. [DOI] [PubMed] [Google Scholar]
- Pullar I. A., Weddell J. M., Ahmed R., Gillingham F. J. Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with L-dopa. J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):851–857. doi: 10.1136/jnnp.33.6.851. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sharman D. F. Glycol metabolites of noradrenaline in brain tissue. Br J Pharmacol. 1969 Jul;36(3):523–534. doi: 10.1111/j.1476-5381.1969.tb08008.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sjöström R., Ekstedt J., Anggård E. Concentration gradients of monoamine metabolites in human cerebrospinal fluid. J Neurol Neurosurg Psychiatry. 1975 Jul;38(7):666–668. doi: 10.1136/jnnp.38.7.666. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sonninen V., Riekkinen P., Rinne U. K. Acid monoamine metabolites in cerebrospinal fluid in multiple sclerosis. Neurology. 1973 Jul;23(7):760–763. doi: 10.1212/wnl.23.7.760. [DOI] [PubMed] [Google Scholar]