Abstract
The myocardial isoenzyme of creatine kinase (MB CK) has been demonstrated in the serum of seven of 16 patients presenting with acute subarachnoid haemorrhage. All patients with elevated MB CK levels exhibited at some stage either intracranial arterial spasm as demonstrated by cerebral angiography, or a focal reversible neurological deficit not due to direct pressure by either intracranial haematoma or aneurysm. The presence of MB CK isoenzymes in sera of patients with subarachnoid haemorrhage may be an index of cerebral ischaemia, and may thus be of value in determining optimal timing of surgery or, ultimately, the long-term prognosis. Changes in the sympathetic nervous system may be a common factor producing both MB isoenzyme release from the myocardium and intracranial arterial spasm.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abildskov J. A., Millar K., Burgess M. J., Vincent W. The electrocardiogram and the central nervous system. Prog Cardiovasc Dis. 1970 Sep;13(2):210–216. doi: 10.1016/0033-0620(70)90009-5. [DOI] [PubMed] [Google Scholar]
- Brownlow K., Elevitch F. R. Serum creatine phosphokinase isoenzyme (CPK2) in myositis. A report of six cases. JAMA. 1974 Nov 25;230(8):1141–1144. [PubMed] [Google Scholar]
- Burch G. E., Sun S. C., Colcolough H. L., DePasquale N. P., Sohal R. S. Acute myocardial lesions; following experimentally-induced intracranial hemorrhage in mice: a histological and histochemical study. Arch Pathol. 1967 Nov;84(5):517–521. [PubMed] [Google Scholar]
- Cao A., De Virgiliis S., Lippi C., Trabalza N. Creatine kinase isoenzymes in serum of children with neurological disorders. Clin Chim Acta. 1969 Mar;23(3):475–478. doi: 10.1016/0009-8981(69)90352-0. [DOI] [PubMed] [Google Scholar]
- Cruickshank J. M., Neil-Dwyer G., Stott A. W. Possible role of catecholamines, corticosteroids, and potassium in production of electrocardiographic abnormalities associated with subarachnoid haemorrhage. Br Heart J. 1974 Jul;36(7):697–706. doi: 10.1136/hrt.36.7.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dubo H., Park D. C., Pennington R. J., Kalbag R. M., Walton J. N. Serum-creatine-kinase in cases of stroke, head injury, and meningitis. Lancet. 1967 Oct 7;2(7519):743–748. doi: 10.1016/s0140-6736(67)91946-0. [DOI] [PubMed] [Google Scholar]
- Greenhoot J. H., Reichenbach D. D. Cardiac injury and subarachnoid hemorrhage. A clinical, pathological, and physiological correlation. J Neurosurg. 1969 May;30(5):521–531. doi: 10.3171/jns.1969.30.5.0521. [DOI] [PubMed] [Google Scholar]
- Hunt D., Gore I. Myocardial lesions following experimental intracranial hemorrhage: prevention with propranolol. Am Heart J. 1972 Feb;83(2):232–236. doi: 10.1016/0002-8703(72)90142-1. [DOI] [PubMed] [Google Scholar]
- Hunt D., McRae C., Zapf P. Electrocardiographic and serum enzyme change in subarachnoid hemorrhage. Am Heart J. 1969 Apr;77(4):479–488. doi: 10.1016/0002-8703(69)90157-4. [DOI] [PubMed] [Google Scholar]
- Klein M. S., Shell W. E., Sobel B. E. Serum creatine phosphokinase (CPK ) isoenzymes after intramuscular injections, surgery, and myocardial infarction. Experimental and clinical studies. Cardiovasc Res. 1973 May;7(3):412–418. doi: 10.1093/cvr/7.3.412. [DOI] [PubMed] [Google Scholar]
- OLIVER I. T. A spectrophotometric method for the determination of creatine phosphokinase and myokinase. Biochem J. 1955 Sep;61(1):116–122. doi: 10.1042/bj0610116. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schiavone D. J., Kaldor J. Creatine phosphokinase levels and cerebral disease. Med J Aust. 1965 Nov 6;2(19):790–792. [PubMed] [Google Scholar]
- Smith A. F., Radford D., Wong C. P., Oliver M. F. Creatine kinase MB isoenzyme studies in diagnosis of myocardial infarction. Br Heart J. 1976 Mar;38(3):225–232. doi: 10.1136/hrt.38.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Somer H., Donner M., Murros J., Konttinen A. A serum isozyme study in muscular dystrophy. Particular reference to creatine kinase, aspartate aminotransferase, and lactic acid dehydrogenase isozymes. Arch Neurol. 1973 Nov;29(5):343–345. doi: 10.1001/archneur.1973.00490290083012. [DOI] [PubMed] [Google Scholar]
- Somer H., Kaste M., Troupp H., Konttinen A. Brain creatine kinase in blood after acute brain injury. J Neurol Neurosurg Psychiatry. 1975 Jun;38(6):572–576. doi: 10.1136/jnnp.38.6.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sundt T. M., Jr Management of ischemic complications after subarachnoid hemorrhage. J Neurosurg. 1975 Oct;43(4):418–425. doi: 10.3171/jns.1975.43.4.0418. [DOI] [PubMed] [Google Scholar]
- Wagner G. S., Roe C. R., Limbird L. E., Rosati R. A., Wallace A. G. The importance of identification of the myocardial-specific isoenzyme of creatine phosphokinase (MB form) in the diagnosis of acute myocardial infarction. Circulation. 1973 Feb;47(2):263–269. doi: 10.1161/01.cir.47.2.263. [DOI] [PubMed] [Google Scholar]
- Weidler D. J. Myocardial damage and cardiac arrhythmias after intracranial hemorrhage. A critical review. Stroke. 1974 Nov-Dec;5(6):759–764. doi: 10.1161/01.str.5.6.759. [DOI] [PubMed] [Google Scholar]