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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1977 Sep;40(9):865–871. doi: 10.1136/jnnp.40.9.865

Role of tissue typing on preserved nerve allografts in dogs

R Singh 1,2,3, K Mechelse 1,2,3, S Stefanko 1,2,3
PMCID: PMC492859  PMID: 340618

Abstract

Histocompatibility seems to play an important role in the regeneration of nerve allografts. Compatible tissue typed nerve allografts behave more like autografts and are, therefore, more readily accepted by the host tissue without producing evident tissue rejection. The influence of histocompatibility difference becomes more marked if the graft is longer than 30-40 mm. Irradiation as a means of reducing the immune reaction of the nerve allografts does not seem to have any beneficial effect along with tissue typing. Preservation of nerve grafts at − 70°C does not have any untoward effect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Das Gupta T. K. Mechanism of rejection of peripheral nerve allografts. Surg Gynecol Obstet. 1967 Nov;125(5):1058–1068. [PubMed] [Google Scholar]
  2. Ducker T. B., Hayes G. J. Peripheral nerve grafts: experimental studies in the dog and chimpanzee to define homograft limitations. J Neurosurg. 1970 Feb;32(2):236–243. doi: 10.3171/jns.1970.32.2.0236. [DOI] [PubMed] [Google Scholar]
  3. Gutmann E., Sanders F. K. Recovery of fibre numbers and diameters in the regeneration of peripheral nerves. J Physiol. 1943 Mar 25;101(4):489–518. doi: 10.1113/jphysiol.1943.sp004002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. MARMOR L. REGENERATION OF PERIPHERAL NERVES BY IRRADIATED HOMOGRAFTS. J Bone Joint Surg Am. 1964 Mar;46:383–394. [PubMed] [Google Scholar]
  5. Millesi H., Meissl G., Berger A. The interfascicular nerve-grafting of the median and ulnar nerves. J Bone Joint Surg Am. 1972 Jun;54(4):727–750. [PubMed] [Google Scholar]
  6. Pollard J. D., McLeod J. G., Gye R. S. Regeneration through peripheral nerve allografts. An electrophysiological and histological study following the use of immunosuppressive therapy. Arch Neurol. 1973 Jan;28(1):31–37. doi: 10.1001/archneur.1973.00490190049005. [DOI] [PubMed] [Google Scholar]

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