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. 1977 Sep;40(9):872–875. doi: 10.1136/jnnp.40.9.872

Antimyelin antibody in multiple sclerosis: no change during immunosuppression

L D Wilkerson 1,2,3,4, R P Lisak 1,2,3,4, B Zweiman 1,2,3,4, D H Silberberg 1,2,3,4
PMCID: PMC492860  PMID: 599363

Abstract

We studied retrospectively levels of antimyelin antibody in a group of 13 multiple sclerosis patients who underwent a clinical trial of long-term, high dose (2.0-4.5 mg/kg/day) azathiaprine therapy. In apparent contrast with collagen vascular disease associated with antitissue antibody, azathiaprine therapy was not associated with significant change in titres of antimyelin antibody. Variation of titre of antimyelin antibody in apparent association with disease activity continued during therapy. No significant changes occurred in levels of serum immunoglobulins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLERAND C. D., YAHR M. D. GAMMA-GLOBULIN AFFINITY FOR NORMAL HUMAN TISSUE OF THE CENTRAL NERVOUS SYSTEM. Science. 1964 May 29;144(3622):1141–1147. doi: 10.1126/science.144.3622.1141. [DOI] [PubMed] [Google Scholar]
  2. Aarli J. A., Aparicio S. R., Lumsden C. E., Tönder O. Binding of normal human IgG to myelin sheaths, glia and neurons. Immunology. 1975 Jan;28(1):171–185. [PMC free article] [PubMed] [Google Scholar]
  3. Davis L. E., Hersh E. M., Curtis J. E., Lynch R. E., Ziegler D. K., Neumann J. W., Chin T. D. Immune status of patients with multiple sclerosis. Analysis of primary and established immune responses in 24 patients. Neurology. 1972 Oct;22(10):989–997. doi: 10.1212/wnl.22.9.989. [DOI] [PubMed] [Google Scholar]
  4. Edgington T. S., Dalessio D. J. The assessment by immunofluorescence methods of humoral anti-myelin antibodies in man. J Immunol. 1970 Jul;105(1):248–255. [PubMed] [Google Scholar]
  5. Jones V. E., Lance E. M., Abbosh J., Graves H. E. Intensive immunosuppression in patients with disseminated sclerosis. II. Tolerance to equine IgG and effect on immunoglobulin and complement levels. Clin Exp Immunol. 1975 Jul;21(1):13–22. [PMC free article] [PubMed] [Google Scholar]
  6. KABAT E. A., FREEDMAN D. A. A study of the crystalline albumin, gamma globulin and total protein in the cerebrospinal fluid of 100 cases of multiple sclerosis and in other diseases. Am J Med Sci. 1950 Jan;219(1):55–64. doi: 10.1097/00000441-195001000-00009. [DOI] [PubMed] [Google Scholar]
  7. LEVIN R. H., LANDY M., FREI E., 3rd THE EFFECT OF 6-MERCAPTOPURINE ON IMMUNE RESPONSE IN MAN. N Engl J Med. 1964 Jul 2;271:16–22. doi: 10.1056/NEJM196407022710103. [DOI] [PubMed] [Google Scholar]
  8. Link H., Müller R. Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch Neurol. 1971 Oct;25(4):326–344. doi: 10.1001/archneur.1971.00490040052007. [DOI] [PubMed] [Google Scholar]
  9. Lisak R. P., Zweiman B. Serum immunogloblin levels in myasthenia gravis, polymyositis, and dermatomyositis. J Neurol Neurosurg Psychiatry. 1976 Jan;39(1):34–37. doi: 10.1136/jnnp.39.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lisak R. P., Zwiman B., Norman M. Antimyelin antibodies in neurologic diseases. Immunofluorescent demonstration. Arch Neurol. 1975 Mar;32(3):163–167. doi: 10.1001/archneur.1975.00490450043005. [DOI] [PubMed] [Google Scholar]
  11. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  12. Silberberg D., Lisak R., Zweiman B. Multiple sclerosis unaffected by azathioprine in pilot study. Arch Neurol. 1973 Mar;28(3):210–212. doi: 10.1001/archneur.1973.00490210090017. [DOI] [PubMed] [Google Scholar]
  13. Swanson M. A., Schwartz R. S. Immunosuppressive therapy. The relation between clinical response and immunologic competence. N Engl J Med. 1967 Jul 27;277(4):163–170. doi: 10.1056/NEJM196707272770401. [DOI] [PubMed] [Google Scholar]

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