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. 1977 Sep;40(9):901–909. doi: 10.1136/jnnp.40.9.901

Whipple's disease confined to the brain: a case studied clinically and pathologically

F C A Romanul 1,2,3, J Radvany 1,2,3, R K Rosales 1,2,3
PMCID: PMC492865  PMID: 74405

Abstract

A 40 year old man developed seizures, intermittent fever, and progressive dementia ending in coma and death after four years. The cerebrospinal fluid showed variable pleocytosis and occasional elevation of protein. The necropsy revealed many lesions characteristic of Whipple's disease confined to the grey matter of the brain. The pathological changes were studied with the light and electron microscope. The findings permitted an understanding of the temporal sequence of changes in the lesions. Involvement of the brain in this condition is rare, but the disease is treatable and the diagnosis can be made by brain biopsy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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