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. 1977 Sep;40(9):910–919. doi: 10.1136/jnnp.40.9.910

Effects of extensor and flexor group I afferent volleys on the excitability of individual soleus motoneurones in man

Peter Ashby 1, Keith Labelle 1
PMCID: PMC492866  PMID: 599368

Abstract

The contour of the postsynaptic potential (PSP) produced in a neurone by an afferent volley can be derived from the contour of the post-stimulus time histogram (PSTH) of that neurone when it is discharging rhythmically. In the present study the PSTH of the firing of individual soleus motor units after stimulation of the popliteal or peroneal nerve was used to explore the effects of extensor and flexor group I afferent volleys on the excitability of single soleus motoneurones in man. Extensor group I volleys resulted in an early peak of increased impulse density in the PSTH of 75% of soleus motoneurones. The latency suggests an analogy with the Ia EPSP. The mean duration of the peak of increased impulse density, equivalent to the rise time of the EPSP, was 3.6 ms. Flexor group I volleys result in a period of reduced impulse density in the PSTH of five out of nine soleus motoneurones. The latency suggests an analogy with the Ia IPSP. We conclude that this method could be used to explore the afferent connections to single motoneurones in man and to derive some of the characteristics of the postsynaptic potentials from a variety of afferent nerve fibres in single human motoneurones.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROCK L. G., COOMBS J. S., ECCLES J. C. The recording of potentials from motoneurones with an intracellular electrode. J Physiol. 1952 Aug;117(4):431–460. doi: 10.1113/jphysiol.1952.sp004759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bouaziz Z., Bouaziz M., Hugon M. Modulation of soleus electromyogram during electrical stimulation of medial gastrocnemius nerve in man. Electromyogr Clin Neurophysiol. 1975 Jan-Apr;15(1):31–41. [PubMed] [Google Scholar]
  3. Bryant H. L., Jr, Marcos A. R., Segundo J. P. Correlations of neuronal spike discharges produced by monosynaptic connections and by common inputs. J Neurophysiol. 1973 Mar;36(2):205–225. doi: 10.1152/jn.1973.36.2.205. [DOI] [PubMed] [Google Scholar]
  4. Buchthal F., Schmalbruch H. Contraction times and fibre types in intact human muscle. Acta Physiol Scand. 1970 Aug;79(4):435–452. doi: 10.1111/j.1748-1716.1970.tb04744.x. [DOI] [PubMed] [Google Scholar]
  5. Buchthal F., Schmalbruch H. Contraction times of twitches evoked by H-reflexes. Acta Physiol Scand. 1970 Nov;80(3):378–382. doi: 10.1111/j.1748-1716.1970.tb04801.x. [DOI] [PubMed] [Google Scholar]
  6. Burke R. E. Group Ia synaptic input to fast and slow twitch motor units of cat triceps surae. J Physiol. 1968 Jun;196(3):605–630. doi: 10.1113/jphysiol.1968.sp008526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Burke R. E., Rymer W. Z. Relative strength of synaptic input from short-latency pathways to motor units of defined type in cat medial gastrocnemius. J Neurophysiol. 1976 May;39(3):447–458. doi: 10.1152/jn.1976.39.3.447. [DOI] [PubMed] [Google Scholar]
  8. COOMBS J. S., ECCLES J. C., FATT P. The inhibitory suppression of reflex discharges from motoneurones. J Physiol. 1955 Nov 28;130(2):396–413. doi: 10.1113/jphysiol.1955.sp005414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Caccia M. R., McComas A. J., Upton A. R., Blogg T. Cutaneous reflexes in small muscles of the hand. J Neurol Neurosurg Psychiatry. 1973 Dec;36(6):960–977. doi: 10.1136/jnnp.36.6.960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Calvin W. H. Generation of spike trains in CNS neurons. Brain Res. 1975 Jan 24;84(1):1–22. doi: 10.1016/0006-8993(75)90796-9. [DOI] [PubMed] [Google Scholar]
  11. ECCLES J. C., ECCLES R. M., IGGO A., ITO M. Distribution of recurrent inhibition among motoneurones. J Physiol. 1961 Dec;159:479–499. doi: 10.1113/jphysiol.1961.sp006822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. ECCLES J. C., ECCLES R. M., LUNDBERG A. The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones. J Physiol. 1957 Jun 18;137(1):22–50. doi: 10.1113/jphysiol.1957.sp005794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. ECCLES R. M., LUNDBERG A. Integrative pattern of Ia synaptic actions on motoneurones of hip and knee muscles. J Physiol. 1958 Dec 4;144(2):271–298. doi: 10.1113/jphysiol.1958.sp006101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Freund H. J., Büdingen H. J., Dietz V. Activity of single motor units from human forearm muscles during voluntary isometric contractions. J Neurophysiol. 1975 Jul;38(4):933–946. doi: 10.1152/jn.1975.38.4.933. [DOI] [PubMed] [Google Scholar]
  15. Gassel M. M., Ott K. H. Local sign and late effects on motoneuron excitability of cutaneous stimulation in man. Brain. 1970;93(1):95–106. doi: 10.1093/brain/93.1.95. [DOI] [PubMed] [Google Scholar]
  16. HAGBARTH K. E. Spinal withdrawal reflexes in the human lower limbs. J Neurol Neurosurg Psychiatry. 1960 Aug;23:222–227. doi: 10.1136/jnnp.23.3.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. HENNEMAN E., SOMJEN G., CARPENTER D. O. FUNCTIONAL SIGNIFICANCE OF CELL SIZE IN SPINAL MOTONEURONS. J Neurophysiol. 1965 May;28:560–580. doi: 10.1152/jn.1965.28.3.560. [DOI] [PubMed] [Google Scholar]
  18. Johnson M. A., Polgar J., Weightman D., Appleton D. Data on the distribution of fibre types in thirty-six human muscles. An autopsy study. J Neurol Sci. 1973 Jan;18(1):111–129. doi: 10.1016/0022-510x(73)90023-3. [DOI] [PubMed] [Google Scholar]
  19. Knox C. K. Cross-correlation functions for a neuronal model. Biophys J. 1974 Aug;14(8):567–582. doi: 10.1016/S0006-3495(74)85936-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Lee R. G., Tatton W. G. Motor responses to sudden limb displacements in primates with specific CNS lesions and in human patients with motor system disorders. Can J Neurol Sci. 1975 Aug;2(3):285–293. doi: 10.1017/s0317167100020382. [DOI] [PubMed] [Google Scholar]
  21. Marsden C. D., Merton P. A., Morton H. B. Servo action in human voluntary movement. Nature. 1972 Jul 21;238(5360):140–143. doi: 10.1038/238140a0. [DOI] [PubMed] [Google Scholar]
  22. McCOUCH G. P., AUSTIN G. M., LIU C. N., LIU C. Y. Sprouting as a cause of spasticity. J Neurophysiol. 1958 May;21(3):205–216. doi: 10.1152/jn.1958.21.3.205. [DOI] [PubMed] [Google Scholar]
  23. Milner-Brown H. S., Stein R. B., Yemm R. The orderly recruitment of human motor units during voluntary isometric contractions. J Physiol. 1973 Apr;230(2):359–370. doi: 10.1113/jphysiol.1973.sp010192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Moore G. P., Segundo J. P., Perkel D. H., Levitan H. Statistical signs of synaptic interaction in neurons. Biophys J. 1970 Sep;10(9):876–900. doi: 10.1016/S0006-3495(70)86341-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Olson C. B., Carpenter D. O., Henneman E. Orderly recruitment of muscle action potentials. Arch Neurol. 1968 Dec;19(6):591–597. doi: 10.1001/archneur.1968.00480060061008. [DOI] [PubMed] [Google Scholar]
  26. Rudomin P., Nuñez R., Madrid J., Burke R. E. Primary afferent hyperpolarization and presynaptic facilitation of Ia afferent terminals induced by large cutaneous fibers. J Neurophysiol. 1974 May;37(3):413–429. doi: 10.1152/jn.1974.37.3.413. [DOI] [PubMed] [Google Scholar]
  27. Schmidt R. F. Presynaptic inhibition in the vertebrate central nervous system. Ergeb Physiol. 1971;63:20–101. doi: 10.1007/BFb0047741. [DOI] [PubMed] [Google Scholar]
  28. Scott J. G., Mendell L. M. Individual EPSPs produced by single triceps surae Ia afferent fibers in homonymous and heteronymous motoneurons. J Neurophysiol. 1976 Jul;39(4):679–692. doi: 10.1152/jn.1976.39.4.679. [DOI] [PubMed] [Google Scholar]
  29. Tanaka R. Activation of reciporcal Ia inhibitory pathway during voluntary motor performance in man. Brain Res. 1972 Aug 25;43(2):649–652. doi: 10.1016/0006-8993(72)90423-4. [DOI] [PubMed] [Google Scholar]
  30. Tanji J., Kato M. Recruitment of motor units in voluntary contraction of a finger muscle in man. Exp Neurol. 1973 Sep;40(3):759–770. doi: 10.1016/0014-4886(73)90110-6. [DOI] [PubMed] [Google Scholar]
  31. Trontelj J. V. A study of the H-reflex by single fibre EMG. J Neurol Neurosurg Psychiatry. 1973 Dec;36(6):951–959. doi: 10.1136/jnnp.36.6.951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Táboríková H., Sax D. S. Conditioning of H-reflexes by a preceding subthreshold H-reflex stimulus. Brain. 1969 Mar;92(1):203–212. doi: 10.1093/brain/92.1.203. [DOI] [PubMed] [Google Scholar]
  33. WILSON V. J., TALBOT W. H., DIECKE F. P. Distribution of recurrent facilitation and inhibition in cat spinal cord. J Neurophysiol. 1960 Mar;23:144–153. doi: 10.1152/jn.1960.23.2.144. [DOI] [PubMed] [Google Scholar]
  34. Wiederholt W. C. Stimulus intensity and site of excitation in human median nerve sensory fibres. J Neurol Neurosurg Psychiatry. 1970 Aug;33(4):438–441. doi: 10.1136/jnnp.33.4.438. [DOI] [PMC free article] [PubMed] [Google Scholar]

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