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. 1977 Oct;40(10):1003–1008. doi: 10.1136/jnnp.40.10.1003

Strumpell's pure familial spastic paraplegia: case study and review of the literature.

G L Holmes, B A Shaywitz
PMCID: PMC492884  PMID: 591968

Abstract

A family with pure Strumpell's familial paraplegia is presented. There were 11 afflicted members involving three generations. The mode of inheritance was dominant, the onset in the first decade, and in this family the disease was mild. Literature data from 104 families with 536 members dating from 1880 are tabulated. This report confirms others regarding mode of inheritance, age of onset, distribution between sexes, and disease manifestations. However, contrary to other reports, we found the dominant and recessive form of pure Strumpell's familial spastic paraplegia to be similar in severity. There are now clinical and pathological data supporting the separation of pure Strumpell's familial spastic paraplegia from the other heredodegenerative diseases of the nervous system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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