. 2016 May 4;157(7):2686–2697. doi: 10.1210/en.2016-1080

Table 1.

Enriched Biological Processes and Core Genes on Fetal Hypothalamic Samples Up- or Down-Regulated by Maternal or Fetal Infusion of TCS

Biological Process	Core Genes	P Value
Up-regulated by TCSM infusion
Mitotic cell cycle	KIF15 \| AURKA \| KIF2C \| SUGT1 \| FBXO5 \| NDC80 \| DLGAP5 \| BIRC5 \| CENPE \| ESPL1 \| MPHOSPH6 \| SMAD3 \| UBE2C \| TPX2 \| KIF11 \| CCNA2 \| BUB1 \| SKP2 \| MAD2L2 \| TTK \| NCAPH \| KNTC1 \| SMC4 \| CDC123 \| PLK1 \| CLIP1 \| KPNA2	<.001
Cell-cell signaling	CGA \| GHRH \| TSHB \| TFAP2C \| POMC \| NPY \| ADM \| CALCA \| GNRH1 \| CCL5 \| TSHR \| PMP22 \| AREG \| EDN3 \| EFNA4 \| TBX3 \| GCH1 \| WISP1 \| CXCL5 \| SST \| KCNN3 \| PTHLH \| GHRL \| SYN2 \| MERTK \| PRG3 \| NQO1 \| GRM5 \| SH2D1A	<.001
Female pregnancy	ADM \| TRO \| SFRP4 \| TAC3 \| FSHB \| OVGP1 \| SPRR2E \| PTHLH \| GHRL \| OXTR \| FLT1	<.001
Cell adhesion	SAA1 \| CYTIP \| IL8 \| EMCN \| TGM2 \| IL12A \| ARHGDIB \| SPN	.003
G protein-coupled receptor	AGRP \| GHRH \| TSHB \| NPY \| CALCA \| TAC3 \| TSHR \| PTAFR \| GCG \| GLP1R \| CD3E \| SST \| IL8 \| PTHLH \| GHRL \| CXCR5 \| SSTR5 \| CRHR1 \| ADRB1 \| GRM5 \| RGS14 \| CXCR6 \| CCR3 \| CCRL2 \| GHRHR \| PTGER1 \| UCN \| CXCR2 \| RGS1 \| PIK3CG \| APOC3 \| HCRTR1 \| ANG \| OPRM1 \| GPRC5C \| CXCL12 \| CXCR4 \| CCL2 \| HRH2 \| APOA1 \| AGTR1	.003
Reproductive process	ADM \| TRO \| SFRP4 \| TAC3 \| ACE2 \| FSHB \| OVGP1 \| TOP2A \| SMAD3 \| TBX3 \| SPRR2E \| IL8 \| PTHLH \| GHRL \| OXTR \| CRHR1 \| IDE \| FLT1 \| CXCR6 \| MKKS	.003
Behavior	AGRP \| SAA1 \| CCL28 \| NPY \| CCL5 \| PTAFR \| GCG \| CXCL5 \| GHRL \| IL8 \| AGTR2 \| BRS3 \| PMCH \| CCR3 \| CCRL2 \| CXCR2 \| SPN \| HCRTR1 \| OPRM1 \| CXCL12 \| CXCR4 \| LECT2 \| CCL2	.005
Down-regulated by TCSM infusion
Chromatin/histone modification	PRMT7 \| KDM4A \| PHB \| KAT5 \| SIRT2 \| UBE2N \| WHSC1L1 \| NSD1 \| RBM14	.03
Protein processing	SCLY \| OAZ1 \| ASRGL1 \| NFS1 \| ADI1 \| WARS \| GCLM \| SLC7A5 \| HGD \| HPRT1 \| BBOX1 \| GLUD1 \| ALDH6A1 \| SLC7A4 \| SMS \| ATF4 \| MAT2B \| PEPD \| BCKDHA \| DHPS \| FPGS \| ALDH5A1 \| CCBL1 \| QDPR \| PAH \| BCAT1 \| DARS \| GOT1 \| PLOD1	.03
Lipoprotein metabolic process	APOA2 \| SCARF1 \| FNTB \| PIGO \| DPM1 \| LDLR \| PPT1	.04
Steroid metabolic Process	SCARB1 \| HSD17B11 \| STARD3 \| STUB1 \| CLN6 \| PPARD \| NPC1 \| APOL2 \| HSD17B6 \| IL4 \|	.05
Fatty acid metabolic process	ACADM \| ADIPOR1 \| ALDH5A1 \| CD74 \| CPT1A \| CROT \| ECHS1 \| FADS2 \| FASN \| HACL1 \| HADHB \| PPARD \| PTGES3	.05
Up-regulated by TCSF infusion
Cell-cell signaling	GHRH \| CXCL10 \| GNRH1 \| SH2D1A \| S100A9 \| MME \| PRG3 \| CALCA \| CCL4 \| CCL15 \| CCL5 \| IL18 \| GCHFR \| CHRNB1 \| TFAP2C \| GRM4 \| TNFRSF11A \| SST \| WISP1 \| SYPL1 \| GCH1 \| AREG \| C1QA \| SNAI2 \| POMC \| NPY \| MGST2 \| SYN2 \| ASIP \| KLF10 \| GRM5 \| CXCL13 \| BMP2 \| INHBA	.005
Inflammatory response	S100A12 \| CXCL10 \| S100A9 \| ANXA1 \| CCL4 \| CCL5 \| HDAC4 \| IL1RAP \| AIF1 \| CYBB	.006
Cytokine production	TLR1 \| PRG3 \| CALCA \| IL6 \| IL18 \| SRGN \| SMAD3 \| TLR3 \| INHBA \| EBI3 \| TLR6 \| HIF1A \| CEBPG \| APOA2 \| SMAD4 \| INHA \| ATP6AP2 \| SFTPD \| MALT1
Regulation of secretion	GHRH \| ANG \| SRGN \| INHBA \| DNAJC1 \| APOA2 \| MYO6 \| INHA	.01
Cellular homeostasis	F2RL1 \| CALCA \| CD55 \| CCL15 \| CCL5 \| MT2A \| ATP1A1 \| SAA1 \| CP \| GPR98	.03
Behavior	CXCL10 \| AGRP \| CCL15 \| CCL5 \| SAA1 \| PMCH \| NPY \| BRS3 \| ACSL4 \| CCL2 \| PLAUR \| CCRL2 \| CXCL13	.04
Down-regulated by TCSF infusion
Chromatin/histone modification	HDAC6 \| CREBBP \| UBE2N \| NSD1 \| SET \| EHMT1 \| RBM14 \| KAT5 \| KDM4A \| SIRT2 \| PPARGC1A	.01
Lipoprotein metabolic process	SCARF1 \| FNTB \| PPT1 \| PIGO \| LDLR	.03
CNS development	EIF2B1 \| TNC \| NNAT \| PROP1 \| UBE3A \| CTNS \| SMARCA1 \| EIF2B2 \| ROBO2 \| S100B \| BTD \| ARNT2 \| PITPNM1 \| DRP2 \| SLIT1 \| BPTF \| PAX6 \| GPR56 \| RNF103 \| SLIT3 \| ALDH5A1 \| NCOA6 \| NPAS2 \| SHH \| PPT1 \| NKX2–2	.03
Gamete generation	FSHB \| CDYL \| PARN \| PICK1 \| USP9 × \| TOB2 \| MAST2 \| HMGCR \| TESK1 \| SERPINA5 \| RUVBL1 \| DEDD \| BRD2	.05

GLP1R, glucagon-like peptide receptor.