Abstract
The effects of discrete increases in the volume of an artificial space-occupying lesion on intracranial pressures and the systemic circulation were studied in six anaesthetised and artificially ventilated dogs. Each increase in volume, accompanied by an increase in supratentorial intracranial pressure, a decrease in supratentorial perfusion pressure, and an increase in transtentorial pressure gradient, induced alterations in the systemic circulation. There were a decrease in heart rate, marked alterations in the arrhythmia index, and increases in stroke volume and systemic vascular resistance. A period of transient systemic hypertension was noted to accompany each discrete increase in intracranial pressure.
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Selected References
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- ALEXANDER S., KERR F. W. BLOOD PRESSURE RESPONSES IN ACUTE COMPRESSION OF THE SPINAL CORD. J Neurosurg. 1964 Jun;21:485–491. doi: 10.3171/jns.1964.21.6.0485. [DOI] [PubMed] [Google Scholar]
- Fitch W., McDowall D. G., Ellis F. R., Paterson G. M., Hain W. R. Effect of elevated intracranial pressure on cardiac output and other circulatory parameters. Br J Anaesth. 1970 Jan;42(1):90–91. [PubMed] [Google Scholar]
- Fitch W., McDowall D. G., Keaney N. P., Pickerodt V. W. Systemic vascular responses to increased intracranial pressure. 2. The 'Cushing' response in the presence of intracranial space-occupying lesions: systemic and cerebral haemodynamic studies in the dog and the baboon. J Neurol Neurosurg Psychiatry. 1977 Sep;40(9):843–852. doi: 10.1136/jnnp.40.9.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fitch W., McDowall D. G. Systemic vascular responses to increased intracranial pressure. 1. Effects of progressive epidural ballon expansion on intracranial pressure: and systemic circulation. J Neurol Neurosurg Psychiatry. 1977 Sep;40(9):833–842. doi: 10.1136/jnnp.40.9.833. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoff J. T., Reis D. J. Localization of regions mediating the Cushing response in CNS of cat. Arch Neurol. 1970 Sep;23(3):228–240. doi: 10.1001/archneur.1970.00480270038006. [DOI] [PubMed] [Google Scholar]
- Johnston I. H., Rowan J. O., Harper A. M., Jennett W. B. Raised intracranial pressure and cerebral blood flow. 2. Supratentorial and infratentorial mass lesions in primates. J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):161–170. doi: 10.1136/jnnp.36.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THOMPSON R. K., MALINA S. Dynamic axial brain-stem distortion as a mechanism explaining the cardiorespiratory changes in increased intracranial pressure. J Neurosurg. 1959 Nov;16:664–675. doi: 10.3171/jns.1959.16.6.0664. [DOI] [PubMed] [Google Scholar]