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. 1978 Jul;41(7):581–588. doi: 10.1136/jnnp.41.7.581

Cerebral transmitter precursors and metabolites in advanced renal disease.

P A Sullivan, D Murnaghan, N Callaghan, B D Kantamaneni, G Curzon
PMCID: PMC493099  PMID: 29080

Abstract

Patients with chronic renal disease had low plasma total tryptophan but an abnormally high proportion of this was in the free state. The subjects with encephalopathy had raised plasma free tryptophan, CSF tryptophan, and CSF 5-hydroxyindoleacetic acid. CSF tryptophan correlated better with plasma free than with plasma total tryptophan. Plasma and CSF tyrosine concentrations were normal but CSF homovanillic acid was raised especially in subjects with encephalopathy. The possible significance of these changes in advanced renal disease is discussed.

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Selected References

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  1. Bloxam D. L., Curzon G., Kantamaneni B. D., Tricklebank M. D. Effects of tryptophan and portocaval anastomosis on activity and brain tryptophan metabolism [proceedings]. Br J Pharmacol. 1977 Jun;60(2):277P–277P. [PMC free article] [PubMed] [Google Scholar]
  2. Bloxam D. L., Warren W. H. Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure. Anal Biochem. 1974 Aug;60(2):621–625. doi: 10.1016/0003-2697(74)90275-9. [DOI] [PubMed] [Google Scholar]
  3. Bridges P. K., Bartlett J. R., Sepping P., Kantamaneni B. D., Curzon G. Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients. Psychol Med. 1976 Aug;6(3):399–405. doi: 10.1017/s003329170001583x. [DOI] [PubMed] [Google Scholar]
  4. Curzon G., Fernando J. C. Drugs altering insulin secretion: effects on plasma and brain concentrations of aromatic amino acids and on brain 5-hydroxytryptamine turnover. Br J Pharmacol. 1977 Jul;60(3):401–408. doi: 10.1111/j.1476-5381.1977.tb07515.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Curzon G., Friedel J., Katamaneni B. D., Greenwood M. H., Lader M. H. Unesterified fatty acids and the binding of tryptophan in human plasma. Clin Sci Mol Med. 1974 Nov;47(5):415–424. doi: 10.1042/cs0470415. [DOI] [PubMed] [Google Scholar]
  6. Curzon G., Kantamaneni B. D., Bartlett J. R., Bridges P. K. Transmitter precursors and metabolites in human ventricular cerebrospinal fluid. J Neurochem. 1976 Mar;26(3):613–615. doi: 10.1111/j.1471-4159.1976.tb01520.x. [DOI] [PubMed] [Google Scholar]
  7. Curzon G., Kantamaneni B. D. Fluorimetric determination of plasma unesterified fatty acid. Clin Chim Acta. 1977 Apr 15;76(2):289–292. doi: 10.1016/0009-8981(77)90109-7. [DOI] [PubMed] [Google Scholar]
  8. Dafny N., Burks T. F. 5-HT and morphine interaction, effects on sensory input in caudate nucleus and substantia nigra. Neuropharmacology. 1977 Sep;16(9):577–585. doi: 10.1016/0028-3908(77)90027-2. [DOI] [PubMed] [Google Scholar]
  9. Essman W. B., Heldman E. Impairment of avoidance acquisition and altered regional brain amine levels in mice with uremic endotoxemia. Physiol Behav. 1972 Jan;8(1):143–146. doi: 10.1016/0031-9384(72)90142-4. [DOI] [PubMed] [Google Scholar]
  10. Fernstrom J. D., Munro H. N., Wurtman R. J. Brain tryptophan in rats on a high fat diet. Nature. 1977 Jan 20;265(5591):277–277. doi: 10.1038/265277a0. [DOI] [PubMed] [Google Scholar]
  11. Fischer J. E., Baldessarini R. J. Pathogenesis and therapy of hepatic coma. Prog Liver Dis. 1976;5:363–397. [PubMed] [Google Scholar]
  12. Gentil V., Lader M. H., Kantamaneni B. D., Curzon G. Effects of adrenaline injection on human plasma tryptophan and non-esterified fatty acids. Clin Sci Mol Med. 1977 Sep;53(3):227–232. doi: 10.1042/cs0530227. [DOI] [PubMed] [Google Scholar]
  13. Gessa G. L., Tagliamonte A. Possible role of free serum tryptophan in the control of brain tryptophan level and serotonin synthesis. Adv Biochem Psychopharmacol. 1974;11(0):119–131. [PubMed] [Google Scholar]
  14. Gulyassy P. F., Peters J. H., Lin S. C., Ryan P. M. Hemodialysis and plasma amino acid composition in chronic renal failure. Am J Clin Nutr. 1968 Jun;21(6):565–573. doi: 10.1093/ajcn/21.6.565. [DOI] [PubMed] [Google Scholar]
  15. Hartmann E., Cravens J., List S. Hypnotic effects of L-tryptophan. Arch Gen Psychiatry. 1974 Sep;31(3):394–397. doi: 10.1001/archpsyc.1974.01760150098014. [DOI] [PubMed] [Google Scholar]
  16. Hutson P. H., Knott P. J., Curzon G. Control of brain tryptophan concentration in rats on a high fat diet. Nature. 1976 Jul 8;262(5564):142–143. doi: 10.1038/262142a0. [DOI] [PubMed] [Google Scholar]
  17. Knott P. J., Curzon G. Free tryptophan in plasma and brain tryptophan metabolism. Nature. 1972 Oct 20;239(5373):452–453. doi: 10.1038/239452a0. [DOI] [PubMed] [Google Scholar]
  18. Knott P. J., Hutson P. H., Curzon G. Fatty acid and tryptophan changes on disturbing groups of rats and caging them singly. Pharmacol Biochem Behav. 1977 Sep;7(3):245–252. doi: 10.1016/0091-3057(77)90141-1. [DOI] [PubMed] [Google Scholar]
  19. MCMENAMY R. H., SEDER R. H. THERMODYNAMIC VALUES RELATED TO THE ASSOCIATION OF L-TRYPTOPHAN ANALOGUES TO HUMAN SERUM ALBUMIN. J Biol Chem. 1963 Oct;238:3241–3248. [PubMed] [Google Scholar]
  20. MEULEMANS O. Determination of total protein in spinal fluid with sulphosalicylic acid and trichloroacetic acid. Clin Chim Acta. 1960 Sep;5:757–761. doi: 10.1016/0009-8981(60)90020-6. [DOI] [PubMed] [Google Scholar]
  21. McMenamy R. H. Binding of indole analogues to human serum albumin. Effects of fatty acids. J Biol Chem. 1965 Nov;240(11):4235–4243. [PubMed] [Google Scholar]
  22. Raskin N. H., Fishman R. A. Neurologic disorders in renal failure (first of two parts). N Engl J Med. 1976 Jan 15;294(3):143–148. doi: 10.1056/NEJM197601152940306. [DOI] [PubMed] [Google Scholar]
  23. Siassi F., Wang M., Kopple J. D., Swendseid M. E. Plasma tryptophan levels and brain serotonin metabolism in chronically uremic rats. J Nutr. 1977 May;107(5):840–845. doi: 10.1093/jn/107.5.840. [DOI] [PubMed] [Google Scholar]
  24. Taylor M. Effects of L-tryptophan and L-methionine on activity in the rat. Br J Pharmacol. 1976 Sep;58(1):117–119. doi: 10.1111/j.1476-5381.1976.tb07699.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Tyler H. R. Neurologic disorders in renal failure. Am J Med. 1968 May;44(5):734–748. doi: 10.1016/0002-9343(68)90255-6. [DOI] [PubMed] [Google Scholar]
  26. Young S. N., Etienne P., Sourkes T. L. Relationship between rat brain and cisternal CSF tryptophan concentrations. J Neurol Neurosurg Psychiatry. 1976 Mar;39(3):239–243. doi: 10.1136/jnnp.39.3.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Young S. N., Garelis E., Lal S., Martin J. B., Molina-Negro P., Ethier R., Sourkes T. L. Tryptophan and 5-hydroxyindoleacetic acid in human cerebrospinal fluid. J Neurochem. 1974 May;22(5):777–779. doi: 10.1111/j.1471-4159.1974.tb04294.x. [DOI] [PubMed] [Google Scholar]
  28. Young S. N., Lal S., Feldmuller F., Sourkes T. L., Ford R. M., Kiely M., Martin J. B. Parallel variation of ventricular CSF tryptophan and free serum tryptophan in man. J Neurol Neurosurg Psychiatry. 1976 Jan;39(1):61–65. doi: 10.1136/jnnp.39.1.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Yuwiler A., Oldendorf W. H., Geller E., Braun L. Effect of albumin binding and amino acid competition on tryptophan uptake into brain. J Neurochem. 1977 May;28(5):1015–1023. doi: 10.1111/j.1471-4159.1977.tb10664.x. [DOI] [PubMed] [Google Scholar]
  30. de Torrente A., Glazer G. B., Gulyassy P. Reduced in vitro binding of tryptophan by plasma in uremia. Kidney Int. 1974 Oct;6(4):222–229. doi: 10.1038/ki.1974.103. [DOI] [PubMed] [Google Scholar]

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