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. 1978 Jul;41(7):593–597. doi: 10.1136/jnnp.41.7.593

Immunological abnormalities and HLA antigen frequencies in IgA deficient patients with epilepsy.

A Fontana, H Joller, F Skvaril, P Grob
PMCID: PMC493101  PMID: 99491

Abstract

Twenty-three epileptics with constitutional factors for seizures and low IgA serum concentrations were studied. Imbalance of the IgG subclasses was often observed, the IgG4 being undetectable in 13 (65%) patients. The percentage of circulating lymphocytes positive for surface immunoglobulins was normal except for slightly increased values for IgA in six (28.5%) patients. Of the epileptics, 48% showed subnormal proportions of lymphocytes forming spontaneous rosettes. There was a distinct trend for HLA-A2 antigen in the patients tested.

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Selected References

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