Abstract
Electrophysiological studies in eight patients with severe motor system abnormalities are described both before and after the start of chronic electrical stimulation of the anterior cerebellum. With stimulation, at least one of following changes was found in seven of these eight patients: reversal of abdominal F amplitude ratios (flexor/extensor muscles), decreased prominence of F responses, and loss of H reflexes in at least one muscle other than the soleus. These changes indicate that cerebellar stimulation can affect the excitability of segmental motoneurone pools. Although clinical changes, particularly decrease in tone, were observed in all the patients with stimulation, the complexity of trying to relate the physiological findings to functional improvement is emphasised.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barnes C. D., Pompeiano O. Inhibition of monosynaptic extensor reflex attributable to presynaptic depolarization of the group Ia afferent fibers produced by vibration of flexor muscle. Arch Ital Biol. 1970 Apr;108(2):233–258. [PubMed] [Google Scholar]
- Cooper I. S., Crighel E., Amin I. Clinical and physiological effects of stimulation of the paleocerebellum in humans. J Am Geriatr Soc. 1973 Jan;21(1):40–43. doi: 10.1111/j.1532-5415.1973.tb00849.x. [DOI] [PubMed] [Google Scholar]
- Cooper I. S., Riklan M., Amin I., Waltz J. M., Cullinan T. Chronic cerebellar stimulation in cerebral palsy. Neurology. 1976 Aug;26(8):744–753. doi: 10.1212/wnl.26.8.744. [DOI] [PubMed] [Google Scholar]
- FRENCH J. H., CLARK D. B., BUTLER H. G., TEASDALL R. D. Phenylketonuria: some observations on reflex activity. J Pediatr. 1961 Jan;58:17–22. doi: 10.1016/s0022-3476(61)80055-3. [DOI] [PubMed] [Google Scholar]
- Fisher M. A. Electrophysiological appraisal of relative segmental motoneurone pool excitability in flexor and extensor. J Neurol Neurosurg Psychiatry. 1978 Jul;41(7):624–629. doi: 10.1136/jnnp.41.7.624. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Garcia-Mullin R., Mayer R. F. H reflexes in acute and chronic hemiplegia. Brain. 1972;95(3):559–572. doi: 10.1093/brain/95.3.559. [DOI] [PubMed] [Google Scholar]
- Gillies J. D., Lance J. W., Neilson P. D., Tassinari C. A. Presynaptic inhibition of the monosynaptic reflex by vibration. J Physiol. 1969 Nov;205(2):329–339. doi: 10.1113/jphysiol.1969.sp008968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAGBARTH K. E. Post-tetanic potentiation of myotatic reflexes in man. J Neurol Neurosurg Psychiatry. 1962 Feb;25:1–10. doi: 10.1136/jnnp.25.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MAGLADERY J. W., TEASDALL R. D., PARK A. M., LANGUTH H. W. Electrophysiological studies of reflex activity in patients with lesions of the nervous system. I. A comparison of spinal motoneurone excitability following afferent nerve volleys in normal persons and patients with upper motor neurone lesions. Bull Johns Hopkins Hosp. 1952 Oct;91(4):219–passim. [PubMed] [Google Scholar]
- Penn R. D., Etzel M. L. Chronic cerebellar stimulation and developmental reflexes. J Neurosurg. 1977 Apr;46(4):506–511. doi: 10.3171/jns.1977.46.4.0506. [DOI] [PubMed] [Google Scholar]
- Penn R. D., Gottlieb G. L., Agarwal G. C. Cerebellar stimulation in man. Quantitative changes in spasticity. J Neurosurg. 1978 May;48(5):779–786. doi: 10.3171/jns.1978.48.5.0779. [DOI] [PubMed] [Google Scholar]
- Sherrington C. S. Decerebrate Rigidity, and Reflex Coordination of Movements. J Physiol. 1898 Feb 17;22(4):319–332. doi: 10.1113/jphysiol.1898.sp000697. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THOMAS J. E., LAMBERT E. H. Ulnar nerve conduction velocity and H-reflex in infants and children. J Appl Physiol. 1960 Jan;15:1–9. doi: 10.1152/jappl.1960.15.1.1. [DOI] [PubMed] [Google Scholar]
- Thorne J. Central responses to electrical activation of the peripheral nerves supplying the intrinsic hand muscles. J Neurol Neurosurg Psychiatry. 1965 Dec;28(6):482–495. doi: 10.1136/jnnp.28.6.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Upton A. R., Cooper I. S. Some neurophysiological effects of cerebellar stimulation in man. Can J Neurol Sci. 1976 Nov;3(4):237–254. doi: 10.1017/s031716710002535x. [DOI] [PubMed] [Google Scholar]
- Upton A. R., McComas A. J., Sica R. E. Potentiation of "late" responses evoked in muscles during effort. J Neurol Neurosurg Psychiatry. 1971 Dec;34(6):699–711. doi: 10.1136/jnnp.34.6.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood J. H., Lake C. R., Ziegler M. G., Sode J., Brooks B. R., Van Buren J. M. Cerebrospinal fluid norepinephrine alterations during electrical stimulation of cerebellar, cerebral surfaces in epileptic patients. Neurology. 1977 Aug;27(8):716–724. doi: 10.1212/wnl.27.8.716. [DOI] [PubMed] [Google Scholar]