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. 2016 Aug;22(8):1215–1227. doi: 10.1261/rna.057208.116

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© 2016 Garcia et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 8. — Alternative splicing changes in Smn missense mutants. (A) Venn diagram of overlapping alternative-splicing changes in Smn missense mutants. (B) Venn diagram of the overlap in shared splicing differences in the Smn missense mutants with either snRNP-dependent changes or Smn gene-specific changes categorized by comparison of the Phax and Smn total rRNA(−) RNA-seq. (C) Browser shot examples of an Smn gene-specific change in alternative-splicing in scarface (top) or a snRNP-dependent change in CG43394 within a PAPLA1 intron on the opposite strand (bottom). Genotypes are labeled by Smn^Tg, which was expressed in the Smn^X7 null background.