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. 1978 Jul;41(7):664–671. doi: 10.1136/jnnp.41.7.664

Painful peripheral states and sympathetic blocks.

L Loh, P W Nathan
PMCID: PMC493113  PMID: 690645

Abstract

In various chronic painful states, the sympathetic nerve supply was blocked either by injecting the sympathetic chain and ganglia with local anaesthesia or by the injection of guanethidine during occlusion of the circulation. There was a striking relation between the presence of hyperpathia and the relief of pain by the blocks. The sympathetic block was unlikely to relieve the pain unless hyperpathia accompanied the pain; when hyperpathia was present, a sympathetic block relieved both the constant pain and the hyperpathia. The effectiveness of the guanethidine blocks shows that the pain and the hyperpathia are maintained by the emission of noradrenaline in the periphery. The facts related to the sympathetic system and sensibility are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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