Abstract
The addition of bromocriptine, given in divided doses up to 30 mg per day, to conventional anti-Parkinsonism therapy has been studied in a double-blind placebo controlled clinical trial in 11 patients with Parkinsonism with the "on-off" syndrome. Four patients withdrew because of side effects. Of the seven remaining, three had clinical benefit from bromocriptine with reduction in severity and frequency of fluctuations. There was, however, no statistically significant benefit of bromocriptine when the group as a whole was assessed in terms of severity or frequency of fluctuations measured by three different methods. The mean frequency of major fluctuations on placebo was 2.9/day and on bromocriptine 1.8/day (P less than 0.1 greater than 0.05). There appears to be a limited role for bromocriptine as additional therapy in the management of some patients with the on-off syndrome.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Calne D. B., Reid J. L., Vakil S. D., Rao S., Petrie A., Pallis C. A., Gawler J., Thomas P. K., Hilson A. Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa. Br Med J. 1971 Sep 25;3(5777):729–732. doi: 10.1136/bmj.3.5777.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Calne D. B., Teychenne P. F., Leigh P. N., Bamji A. N., Greenacre J. K. Treatment of parkinsonism with bromocriptine. Lancet. 1974 Dec 7;2(7893):1355–1356. doi: 10.1016/s0140-6736(74)92219-3. [DOI] [PubMed] [Google Scholar]
- Greenacre J. K., Coxon A., Petrie A., Reid J. L. Comparison of levodopa with carbidopa or benserazide in parkinsonism. Lancet. 1976 Aug 21;2(7982):381–384. doi: 10.1016/s0140-6736(76)92403-x. [DOI] [PubMed] [Google Scholar]
- Johnson A. M., Loew D. M., Vigouret J. M. Stimulant properties of bromocriptine on central dopamine receptors in comparison to apomorphine, (+)-amphetamine and L-DOPA. Br J Pharmacol. 1976 Jan;56(1):59–68. doi: 10.1111/j.1476-5381.1976.tb06959.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kartznel R., Calne D. B. Studies with bromocriptine. Part 1. "On-off" phenomena. Neurology. 1976 Jun;26(6 Pt 1):508–510. doi: 10.1212/wnl.26.6.508. [DOI] [PubMed] [Google Scholar]
- Lees A. J., Shaw K. M., Kohout L. J., Stern G. M., Elsworth J. D., Sandler M., Youdim M. B. Deprenyl in Parkinson's disease. Lancet. 1977 Oct 15;2(8042):791–795. doi: 10.1016/s0140-6736(77)90725-5. [DOI] [PubMed] [Google Scholar]
- Lieberman A., Kupersmith M., Estey E., Goldstein M. Treatment of parkinson's disease with bromocriptine. N Engl J Med. 1976 Dec 16;295(25):1400–1404. doi: 10.1056/NEJM197612162952504. [DOI] [PubMed] [Google Scholar]
- Marsden C. D., Parkes J. D. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet. 1977 Feb 12;1(8007):345–349. doi: 10.1016/s0140-6736(77)91146-1. [DOI] [PubMed] [Google Scholar]
- Moore K. E., Thornburg J. E. Drug-induced dopaminergic supersensitivity. Adv Neurol. 1975;9:93–104. [PubMed] [Google Scholar]
- Sweet R. D., McDowell F. H., Feigenson J. S., Loranger A. W., Goodell H. Mental symptoms in Parkinson's disease during chronic treatment with levodopa. Neurology. 1976 Apr;26(4):305–310. doi: 10.1212/wnl.26.4.305. [DOI] [PubMed] [Google Scholar]
- Sweet R. D., McDowell F. H. The "on-off" response to chronic L-DOPA treatment of Parkinsonism. Adv Neurol. 1974;5:331–338. [PubMed] [Google Scholar]
- Teychenne P. F., Leigh P. N., Reid J. L., Calne D. B., Greenacre J. K., Petrie A., Bamji A. N. Idiopathic parkinsonism treated with bromocriptine. Lancet. 1975 Sep 13;2(7933):473–476. doi: 10.1016/s0140-6736(75)90546-2. [DOI] [PubMed] [Google Scholar]