Abstract
In patients suffering from various platelet abnormalities, quantitative scanning after injection of indium-111 (111In) labelled platelets showed three different patterns of platelet destruction and distribution. In patients with a normal platelet life span but with evidence of increased splenic pooling, the spleen tended to be the main site of destruction. In patients with a moderately reduced platelet life span, the distribution of destruction in the system and variable destruction in the marrow. However, because of its rapidity this destruction was difficult to quantify, and it was difficult in these cases to distinguish reliably between spleen pool, sequestration, and destruction. Destruction of platelets on the liver appeared to be unimportant in all three groups. 111In, because of its physical characteristics, is preferable to chromium-51 as a platelet label in the assessment of abnormal platelet kinetics.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ASTER R. H., JANDL J. H. PLATELET SEQUESTRATION IN MAN. II. IMMUNOLOGICAL AND CLINICAL STUDIES. J Clin Invest. 1964 May;43:856–869. doi: 10.1172/JCI104971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Aster R. H., Keene W. R. Sites of platelet destruction in idiopathic thrombocytopenic purpura. Br J Haematol. 1969 Jan-Feb;16(1):61–73. doi: 10.1111/j.1365-2141.1969.tb00379.x. [DOI] [PubMed] [Google Scholar]
- Goodwin D. A., Bushberg J. T., Doherty P. W., Lipton M. J., Conley F. K., Diamanti C. I., Meares C. F. Indium-111-labeled autologous platelets for location of vascular thrombi in humans. J Nucl Med. 1978 Jun;19(6):626–634. [PubMed] [Google Scholar]
- Heyns A. D., Lötter M. G., Badenhorst P. N., van Reenen O. R., Pieters H., Minnaar P. C., Retief F. P. Kinetics, distribution and sites of destruction of 111indium-labelled human platelets. Br J Haematol. 1980 Feb;44(2):269–280. doi: 10.1111/j.1365-2141.1980.tb01209.x. [DOI] [PubMed] [Google Scholar]
- Klonizakis I., Peters A. M., Fitzpatrick M. L., Kensett M. J., Lewis S. M., Lavender J. P. Radionuclide distribution following injection of 111Indium-labelled platelets. Br J Haematol. 1980 Dec;46(4):595–602. doi: 10.1111/j.1365-2141.1980.tb06017.x. [DOI] [PubMed] [Google Scholar]
- Najean Y., Ardaillou N., Dresch C., Bernard J. The platelet destruction site in thrombocytopenic purpuras. Br J Haematol. 1967 May;13(3):409–426. doi: 10.1111/j.1365-2141.1967.tb08755.x. [DOI] [PubMed] [Google Scholar]
- Najean Y., Ardaillou N. The sequestration site of platelets in idiopathic thrombocytopenic purpura: its correlation with the results of splenectomy. Br J Haematol. 1971 Aug;21(2):153–164. doi: 10.1111/j.1365-2141.1971.tb03425.x. [DOI] [PubMed] [Google Scholar]
- Thakur M. L., Coleman R. E., Welch M. J. Indium-111-labeled leukocytes for the localization of abscesses: preparation, analysis, tissue distribution, and comparison with gallium-67 citrate in dogs. J Lab Clin Med. 1977 Jan;89(1):217–228. [PubMed] [Google Scholar]
- Williams E. D., Merrick M. V., Lavender J. P. The distribution and dosimetry of 111-IN-bleomycin in man. Br J Radiol. 1975 Apr;48(568):275–278. doi: 10.1259/0007-1285-48-568-275. [DOI] [PubMed] [Google Scholar]