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The Journal of Biological Chemistry logoLink to The Journal of Biological Chemistry
. 2016 Jul 1;291(27):14392. doi: 10.1074/jbc.A113.529925

Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) in response to high calorie diet intake.

Sabeera Bonala, Sudarsanareddy Lokireddy, Craig McFarlane, Sreekanth Patnam, Mridula Sharma, Ravi Kambadur
PMCID: PMC4933197  PMID: 27371568

VOLUME 289 (2014) PAGES 7654–7670

This article has been withdrawn by the authors. In this article, we reported a mechanism through which myostatin induces insulin resistance. After a thorough investigation by the Nanyang Technological University in Singapore, data falsifications were found in some of the in vitro laboratory studies, which invalidate the results reported. Thus, the co-authors wish to withdraw this publication and offer our sincere apologies to all those investigators who may have been affected and misled by this.


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