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The Journal of Biological Chemistry logoLink to The Journal of Biological Chemistry
. 2016 Jun 3;291(23):12039. doi: 10.1074/jbc.A115.695478

Astrocyte resilience to oxidative stress induced by insulin-like growth factor I (IGF-I) involves preserved AKT (protein kinase B) activity.

David Dávila, Silvia Fernández, Ignacio Torres-Alemán
PMCID: PMC4933256  PMID: 27261528

VOLUME 291 (2016) PAGES 2510–2523

This article has been withdrawn by the authors. The pAKT and AKT immunoblots in Fig. 1C and the DAPI and DCF2 staining for control cells treated with either vehicle or IGF-I in Fig. 5A were published previously in Figs. 3E and 4B, respectively, from Genis, L., Dávila, D, Fernandez, S., Pozo-Rodrigálvarez, A., Martínez-Murillo, R., and Torres-Aleman, I. (2014) Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury. F1000Res 3, 28 (10.12688/f1000research.3-28.v2). Fig. 2A was published previously in Fig. 3C in Dávila, D. and Torres-Aleman, I. (2008) Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling. Mol. Biol. Cell 19, 2014–2025.


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