Abstract
A correlative clinical and Hemalog D study of 80 cases of chronic lymphocytic leukaemia (CLL) was performed and the results compared with those in other lymphoproliferative disorders affecting the blood (eight cases of hairy-cell leukaemia, HCL; three cases of prolymphocytic leukaemia, PLL: two cases of lymphoplasmacytoid proliferation, LPP; and one case of Sézary's syndrome, SS). In CLL the mean percentage and absolute counts of large unstained cells (LUC) were 8.7% and 6.2 x 109/1 (6200/mm3), and the percentage of LUCs was not substantially affected by treatment; there was no correlation between LUCs and Rai clinical stage. SS and LPP were characterised by a similar percentage of LUCs, but both HCL and PLL were distinguished by a higher mean percentage of LUCs. Stage IV CLL was associated with monocytopenia, but other stages of CLL, PLL, LPP, and SS showed no consistent reduction of absolute numbers of non-lymphoid cell types. In contrast, HCL was characterised by a consistent absolute neutropenia and monocytopenia which distinguished its Hemalog D profile from that of PLL.
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- Binet J. L., Leporrier M., Dighiero G., Charron D., D'Athis P., Vaugier G., Beral H. M., Natali J. C., Raphael M., Nizet B. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer. 1977 Aug;40(2):855–864. doi: 10.1002/1097-0142(197708)40:2<855::aid-cncr2820400239>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
- Binet J. L., Vaugier G., Dighiero G., d'Athis P., Charron D. Investigation of a new parameter in chronic lymphocytic leukemia: the percentage of large peripheral lymphocytes determined by the Hemalog D. Prognostic significance. Am J Med. 1977 Nov;63(5):683–688. doi: 10.1016/0002-9343(77)90152-8. [DOI] [PubMed] [Google Scholar]
- Braylan R. C., Jaffe E. S., Triche T. J., Nanba K., Fowlkes B. J., Metzger H., Frank M. M., Dolan M. S., Yee C. L., Green I. Structural and functional properties of the "hairy" cells of leukemic reticuloendotheliosis. Cancer. 1978 Jan;41(1):210–227. doi: 10.1002/1097-0142(197801)41:1<210::aid-cncr2820410130>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
- Costello C., Wardle J., Catovsky D., Lewis S. M. Cell volume studies in B-cell leukaemia. Br J Haematol. 1980 Jun;45(2):209–214. doi: 10.1111/j.1365-2141.1980.tb07140.x. [DOI] [PubMed] [Google Scholar]
- Dubner H. N., Crowley J. J., Schilling R. F. Prognostic value of nucleoli and cell size in chronic lymphocytic leukemia. Am J Hematol. 1978;4(4):337–341. doi: 10.1002/ajh.2830040405. [DOI] [PubMed] [Google Scholar]
- Goldsmith M. A., Carter S. K. Combination chemotherapy of advanced Hodgkin's disease. A review. Cancer. 1974 Jan;33(1):1–8. doi: 10.1002/1097-0142(197401)33:1<1::aid-cncr2820330102>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- Peterson L. C., Bloomfield C. D., Brunning R. D. Relationship of clinical staging and lymphocyte morphology to survival in chronic lymphocytic leukaemia. Br J Haematol. 1980 Apr;44(4):563–567. doi: 10.1111/j.1365-2141.1980.tb08710.x. [DOI] [PubMed] [Google Scholar]
- Peterson L. C., Bloomfield C. D., Sundberg R. D., Gajl-Peczalska K. J., Brunning R. D. Morphology of chronic lymphocytic leukemia and its relationship to survival. Am J Med. 1975 Sep;59(3):316–324. doi: 10.1016/0002-9343(75)90389-7. [DOI] [PubMed] [Google Scholar]
- Rai K. R., Sawitsky A., Cronkite E. P., Chanana A. D., Levy R. N., Pasternack B. S. Clinical staging of chronic lymphocytic leukemia. Blood. 1975 Aug;46(2):219–234. [PubMed] [Google Scholar]