Abstract
Eighty-four children with acute lymphoblastic leukaemia (ALL) who had relapsed in bone marrow were studied to assess whether treatment would be more successful if relapse was detected before the disease became clinically evident. Patients whose relapse was detected by routine bone marrow examination before the disease became apparent were compared with those whose relapse was suspected from clinical examination or peripheral blood findings. In the former there was a lower percentage of blast cells in the marrow (p less than 0.02) and the patients suffered less from complications of the disease, but there was no difference in the incidence or duration of second remissions between the two groups.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Crowther D., Beard M. E., Bateman C. J., Sewell R. L. Factors influencing prognosis in adults with acute myelogenous leukaemia. Br J Cancer. 1975 Oct;32(4):456–464. doi: 10.1038/bjc.1975.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Durie B. G., Salmon S. E. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975 Sep;36(3):842–854. doi: 10.1002/1097-0142(197509)36:3<842::aid-cncr2820360303>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
- Gehan E. A., Smith T. L., Freireich E. J., Bodey G., Rodriquez V., Speer J., McCredie K. Prognostic factors in acute leukemia. Semin Oncol. 1976 Sep;3(3):271–282. [PubMed] [Google Scholar]
- Keating M. J., Smith T. L., Gehan E. A., McCredie K. B., Bodey G. P., Spitzer G., Hersh E., Gutterman J., Freireich E. J. Factors related to length of complete remission in adult acute leukemia. Cancer. 1980 Apr 15;45(8):2017–2029. doi: 10.1002/1097-0142(19800415)45:8<2017::aid-cncr2820450806>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- Magrath I., Lee Y. J., Anderson T., Henle W., Ziegler J., Simon R., Schein P. Prognostic factors in Burkitt's lymphoma: importance of total tumor burden. Cancer. 1980 Mar 15;45(6):1507–1515. doi: 10.1002/1097-0142(19800315)45:6<1507::aid-cncr2820450634>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
- Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]