Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1981 May;34(5):504–508. doi: 10.1136/jcp.34.5.504

Plasma fibronectin in normal subjects and in various disease states.

N E Stathakis, A Fountas, E Tsianos
PMCID: PMC493333  PMID: 7251892

Abstract

Plasma fibronectin was determined in 121 normal adults and in 149 patients. Fibronectin levels in normals were strongly influenced by sex and age. The mean value of the protein in cancer patients did not differ from that in normal controls; however, patients with cryofibrinogenaemia or extensive liver metastases had lower values whereas those with obstructive jaundice due to pancreatic carcinoma had higher values than normal controls. Fibronectin levels were greatly increased in patients with primary biliary cirrhosis and moderately elevated in nephrotic syndrome. In patients with severe infection or sepsis, plasma fibronectin did not show a consistent pattern. Patients with overt disseminated intravascular coagulation, irrespective of its cause, had the lowest plasma fibronectin concentrations.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bruhn H. D., Heimburger N. Factor-VIII-related antigen and cold-insoluble globulin in leukemias and carcinomas. Haemostasis. 1976;5(3):189–192. doi: 10.1159/000214134. [DOI] [PubMed] [Google Scholar]
  2. Chen A. B., Mosesson M. W. An improved method for purification of the cold-insoluble globulin of human plasma (CLg). Anal Biochem. 1977 May 1;79(1-2):144–151. doi: 10.1016/0003-2697(77)90388-8. [DOI] [PubMed] [Google Scholar]
  3. Forkman B., Ganrot P. O., Gennser G., Rannevik G. Plasma protein pattern in recurrent cholestasis of pregnancy. Scand J Clin Lab Invest Suppl. 1972;124:89–96. doi: 10.3109/00365517209102756. [DOI] [PubMed] [Google Scholar]
  4. Fyrand O., Solum N. L. Studies on cold insoluble globulin in dermatological patients. I. Immunochemical quantitation in citrated plasma from patients with increased amounts of heparin precipitable fraction (HPF). Thromb Res. 1976 Nov;9(5):447–455. doi: 10.1016/0049-3848(76)90200-0. [DOI] [PubMed] [Google Scholar]
  5. Ganrot P. O. Variation of the concentrations of some plasma proteins in normal adults, in pregnant women and in newborns. Scand J Clin Lab Invest Suppl. 1972;124:83–88. doi: 10.3109/00365517209102755. [DOI] [PubMed] [Google Scholar]
  6. Gold L. I., Pearlstein E. Fibronectin-collagen binding and requirement during cellular adhesion. Biochem J. 1980 Feb 15;186(2):551–559. doi: 10.1042/bj1860551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hörmann H., Jelinić V. Fibronectin, VII. Binding of cold-insoluble globulin and of denatured collagen by macrophages. Hoppe Seylers Z Physiol Chem. 1980;361(3):379–387. doi: 10.1515/bchm2.1980.361.1.379. [DOI] [PubMed] [Google Scholar]
  8. Laurell C. B. Electroimmuno assay. Scand J Clin Lab Invest Suppl. 1972;124:21–37. doi: 10.3109/00365517209102748. [DOI] [PubMed] [Google Scholar]
  9. Matsuda M., Yoshida N., Aoki N., Wakabayashi K. Distribution of cold-insoluble globulin in plasma and tissues. Ann N Y Acad Sci. 1978 Jun 20;312:74–92. doi: 10.1111/j.1749-6632.1978.tb16794.x. [DOI] [PubMed] [Google Scholar]
  10. Mosesson M. W., Chen A. B., Huseby R. M. The cold-insoluble globulin of human plasma: studies of its essential structural features. Biochim Biophys Acta. 1975 Apr 29;386(2):509–524. doi: 10.1016/0005-2795(75)90294-9. [DOI] [PubMed] [Google Scholar]
  11. Mosesson M. W., Umfleet R. A. The cold-insoluble globulin of human plasma. I. Purification, primary characterization, and relationship to fibrinogen and other cold-insoluble fraction components. J Biol Chem. 1970 Nov 10;245(21):5728–5736. [PubMed] [Google Scholar]
  12. Mosher D. F. Changes in plasma could-insoluble globulin concentration during experimental Rocky Mountain spotted fever infection in rhesus monkeys. Thromb Res. 1976 Jul;9(1):37–45. doi: 10.1016/0049-3848(76)90147-x. [DOI] [PubMed] [Google Scholar]
  13. Mosher D. F. Cross-linking of cold-insoluble globulin by fibrin-stabilizing factor. J Biol Chem. 1975 Aug 25;250(16):6614–6621. [PubMed] [Google Scholar]
  14. Mosher D. F., Williams E. M. Fibronectin concentration is decreased in plasma of severely ill patients with disseminated intravascular coagulation. J Lab Clin Med. 1978 May;91(5):729–735. [PubMed] [Google Scholar]
  15. RATNOFF O. D., MENZIE C. A new method for the determination of fibrinogen in small samples of plasma. J Lab Clin Med. 1951 Feb;37(2):316–320. [PubMed] [Google Scholar]
  16. Ruoslahti E., Engvall E. Immunochemical and collagen-binding properties of fibronectin. Ann N Y Acad Sci. 1978 Jun 20;312:178–191. doi: 10.1111/j.1749-6632.1978.tb16802.x. [DOI] [PubMed] [Google Scholar]
  17. Ruoslahti E., Vaheri A. Interaction of soluble fibroblast surface antigen with fribrinogen and fibrin. J Exp Med. 1975 Feb 1;141(2):497–501. doi: 10.1084/jem.141.2.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stathakis N. E., Mosesson M. W., Chen A. B., Galanakis D. K. Cryoprecipitation of fibrin-fibrinogen complexes induced by the cold-insoluble globulin of plasma. Blood. 1978 Jun;51(6):1211–1222. [PubMed] [Google Scholar]
  19. Stathakis N. E., Mosesson M. W. Interactions among heparin, cold-insoluble globulin, and fibrinogen in formation of the heparin-precipitable fraction of plasma. J Clin Invest. 1977 Oct;60(4):855–865. doi: 10.1172/JCI108840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stemberger A., Hörmann H. Affinity chromatography on immobilized fibrinogen and fibrin monomer, II. The behavior of cold-insoluble globulin [1]. Hoppe Seylers Z Physiol Chem. 1976 Jul;357(7):1003–1005. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES