Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1981 May;34(5):532–541. doi: 10.1136/jcp.34.5.532

Condylomata of the uterine cervix and koilocytosis of cervical intraepithelial neoplasia.

S Pilotti, F Rilke, G De Palo, G Della Torre, L Alasio
PMCID: PMC493338  PMID: 6265503

Abstract

In 202 women with koilocytotic atypia in cervical smears, 136 had predominantly small condylomata of the uterine cervix, and 66 had cervical intraepithelial neoplasia (CIN) of varying degree either with koilocytosis of the neoplasia or associated with condylomata. Koilocytosis correlated well with the histological diagnosis of condylomata, but occasionally it obscured the cytological evidence of CIN. Human papilloma virus particles were found in the cells of condylomata in 10 cases and in those of CIN II with koilocytosis in two cases of 21 examined ultrastructurally. There was evidence that the condyloma of the uterine cervix is a well-defined morphological entity and also that cytopathie changes similar to those seen in condylomata are present in some cases of CIN.

Full text

PDF
532

Images in this article

534Image
on p.534
534Image
on p.534
535Image
on p.535
535Image
on p.535
536Image
on p.536
537Image
on p.537
538Image
on p.538
538Image
on p.538
539Image
on p.539
539Image
on p.539

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashley D. J. The biological status of carcinoma in-situ of the uterine cervix. J Obstet Gynaecol Br Commonw. 1966 Jun;73(3):372–381. doi: 10.1111/j.1471-0528.1966.tb05177.x. [DOI] [PubMed] [Google Scholar]
  2. Cocks P. S., Peel K. R., Cartwright R. A., Adib R. Carcinoma of penis and cervix. Lancet. 1980 Oct 18;2(8199):855–856. doi: 10.1016/s0140-6736(80)90195-6. [DOI] [PubMed] [Google Scholar]
  3. Della Torre G., Pilotti S., de Palo G., Rilke F. Viral particles in cervical condylomatous lesions. Tumori. 1978 Oct 31;64(5):549–553. doi: 10.1177/030089167806400513. [DOI] [PubMed] [Google Scholar]
  4. Dun A. E., Ogilvie M. M. Intranuclear virus particles in human genital wart tissue: observations on the ultrastructure of the epidermal layer. J Ultrastruct Res. 1968 Feb;22(3):282–295. doi: 10.1016/s0022-5320(68)90021-x. [DOI] [PubMed] [Google Scholar]
  5. Friedman J. M., Fialkow P. J. Viral "tumorigenesis" in man: cell markers in condylomata acuminata. Int J Cancer. 1976 Jan 15;17(1):57–61. doi: 10.1002/ijc.2910170109. [DOI] [PubMed] [Google Scholar]
  6. Hills E., Laverty C. R. Electron microscopic detection of papilloma virus particles in selected koilocytotic cells in a routine cervical smear. Acta Cytol. 1979 Jan-Feb;23(1):53–56. [PubMed] [Google Scholar]
  7. KOSS L. G., DURFEE G. R. Unusual patterns of squamous epithelium of the uterine cervix: cytologic and pathologic study of koilocytotic atypia. Ann N Y Acad Sci. 1956 Mar 30;63(6):1245–1261. doi: 10.1111/j.1749-6632.1956.tb32134.x. [DOI] [PubMed] [Google Scholar]
  8. Kaufman R. H. Dysplasia and carcinoma in situ of the cervix. Clin Obstet Gynecol. 1967 Dec;10(4):748–784. [PubMed] [Google Scholar]
  9. Kessler I. I. Human cervical cancer as a venereal disease. Cancer Res. 1976 Feb;36(2 Pt 2):783–791. [PubMed] [Google Scholar]
  10. Kirkup W., Singer A., Hill A. S. Follow-up of women treated for cervical precancer: an argument for a more rational approach. Lancet. 1979 Jul 7;2(8132):22–24. doi: 10.1016/s0140-6736(79)90184-3. [DOI] [PubMed] [Google Scholar]
  11. Komorowski R., Clowry L., Jr Koilocytotic atypia of the cervix. Obstet Gynecol. 1976 May;47(5):540–544. [PubMed] [Google Scholar]
  12. Laurent R., Coume-Marquet S., Kienzler J. L., Lambert D., Agache P. Comparative electron microscopic study of clear cells in epidermodysplasia verruciformis and flat warts. Arch Dermatol Res. 1978;263(1):1–12. [PubMed] [Google Scholar]
  13. Laverty C. R., Booth N., Hills E., Cossart Y., Wills E. J. Noncondylomatous wart virus infection of the postmenopausal cervix. Pathology. 1978 Oct;10(4):373–378. doi: 10.3109/00313027809063526. [DOI] [PubMed] [Google Scholar]
  14. Laverty C. R., Russell P., Hills E., Booth N. The significance of noncondylomatous wart virus infection of the cervical transformation zone. A review with discussion of two illustrative cases. Acta Cytol. 1978 Jul-Aug;22(4):195–201. [PubMed] [Google Scholar]
  15. McDougall J. K., Galloway D. A., Fenoglio C. M. Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change. Int J Cancer. 1980 Jan 15;25(1):1–8. doi: 10.1002/ijc.2910250102. [DOI] [PubMed] [Google Scholar]
  16. Meisels A., Fortin R. Condylomatous lesions of the cervix and vagina. I. Cytologic patterns. Acta Cytol. 1976 Nov-Dec;20(6):505–509. [PubMed] [Google Scholar]
  17. Meisels A., Fortin R., Roy M. Condylomatous lesions of the cervix. II. Cytologic, colposcopic and histopathologic study. Acta Cytol. 1977 May-Jun;21(3):379–390. [PubMed] [Google Scholar]
  18. Morin C., Meisels A. Human papilloma virus infection of the uterine cervix. Acta Cytol. 1980 Jan-Feb;24(1):82–84. [PubMed] [Google Scholar]
  19. Okagaki T., Clark B. A., Brooker D. C., Williams P. P. Koilocytosis in dysplastic and reactive cervical squamous epithelium. An ultrastructural study. Acta Cytol. 1978 Mar-Apr;22(2):95–98. [PubMed] [Google Scholar]
  20. Oriel J. D., Almeida J. D. Demonstration of virus particles in human genital warts. Br J Vener Dis. 1970 Feb;46(1):37–42. doi: 10.1136/sti.46.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Oriel J. D. Anal warts and anal coitus. Br J Vener Dis. 1971 Oct;47(5):373–376. doi: 10.1136/sti.47.5.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Oriel J. D. Natural history of genital warts. Br J Vener Dis. 1971 Feb;47(1):1–13. doi: 10.1136/sti.47.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Purola E., Savia E. Cytology of gynecologic condyloma acuminatum. Acta Cytol. 1977 Jan-Feb;21(1):26–31. [PubMed] [Google Scholar]
  24. Reid R., Laverty C. R., Coppleson M., Isarangkul W., Hills E. Noncondylomatous cervical wart virus infection. Obstet Gynecol. 1980 Apr;55(4):476–483. [PubMed] [Google Scholar]
  25. Waugh M. Condylomata acuminata. Br Med J. 1972 May 27;2(5812):527–528. doi: 10.1136/bmj.2.5812.527-d. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. zur Hausen H. Human papillomaviruses and their possible role in squamous cell carcinomas. Curr Top Microbiol Immunol. 1977;78:1–30. doi: 10.1007/978-3-642-66800-5_1. [DOI] [PubMed] [Google Scholar]
  27. zur Hausen H., Meinhof W., Scheiber W., Bornkamm G. W. Attempts to detect virus-secific DNA in human tumors. I. Nucleic acid hybridizations with complementary RNA of human wart virus. Int J Cancer. 1974 May 15;13(5):650–656. doi: 10.1002/ijc.2910130509. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES