Abstract
Calcium uptake on muscle microsomal fraction has been investigated in connection with bioelectrical activity in some muscle diseases. The findings showed a significant increase of calcium uptake in denervated muscle, which exhibited spontaneous bioelectrical activity (fibrillations). In myotonias, a low calcium uptake was peculiar to Steinert's disease but not to myotonia congenita. In other muscle diseases, such as progressive muscular dystrophy (Duchenne's type) or Charcot-Marie-Tooth's disease, the ability of muscle microsomal fraction to bind calcium was not changed. Starting with the key role of calcium in excitation-contraction coupling, the implications of calcium uptake disturbances in muscle electrogenesis are discussed.
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- Brody I. A. Relaxing factor in denervated muscle: a possible explanation for fibrillations. Am J Physiol. 1966 Dec;211(6):1277–1280. doi: 10.1152/ajplegacy.1966.211.6.1277. [DOI] [PubMed] [Google Scholar]
- Brooke M. H., Engel W. K. The histographic analysis of human muscle biopsies with regard to fiber types. 3. Myotonias, myasthenia gravis, and hypokalemic periodic paralysis. Neurology. 1969 May;19(5):469–477. doi: 10.1212/wnl.19.5.469. [DOI] [PubMed] [Google Scholar]
- Howell J. N., Fairhurst A. S., Jenden D. J. Alterations of the calcium accumulating ability of striated muscle following denervation. Life Sci. 1966 Mar;5(5):439–446. doi: 10.1016/0024-3205(66)90159-7. [DOI] [PubMed] [Google Scholar]
- Kuhn E., Stein W. Modellmyotonie nach 2,4-Dichlorphenoxyacetat (2,4-D). Calciumaufnahme der Vesikel des sarkoplasmatischen Reticulums unter 2,4-D. Klin Wochenschr. 1966 Jun 15;44(12):700–702. doi: 10.1007/BF01790794. [DOI] [PubMed] [Google Scholar]
- Lenman J. A. Effect of denervation on the resting membrane potential of healthy and dystrophic muscle. J Neurol Neurosurg Psychiatry. 1965 Dec;28(6):525–528. doi: 10.1136/jnnp.28.6.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McComas A. J., Mrozek K. Denervated muscle fibres in hereditary mouse dystrophy. J Neurol Neurosurg Psychiatry. 1967 Dec;30(6):526–530. doi: 10.1136/jnnp.30.6.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NACHLAS M. M., TSOU K. C., DE SOUZA E., CHENG C. S., SELIGMAN A. M. Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole. J Histochem Cytochem. 1957 Jul;5(4):420–436. doi: 10.1177/5.4.420. [DOI] [PubMed] [Google Scholar]
- Nastuk W. L., Liu J. H. Muscle postjunctional membrane: changes in chemosensitivity produced by calcium. Science. 1966 Oct 14;154(3746):266–267. doi: 10.1126/science.154.3746.266. [DOI] [PubMed] [Google Scholar]
- RIECKER G., DOBBELSTEIN H., ROEHL D., BOLTE H. D. MESSUNGEN DES MEMBRANPOTENTIALS EINZELMER QUERGESTREIFTER MUSKELZELLEN BEI MYOTONIA CONGENITA (THOMSEN) Klin Wochenschr. 1964 Jun 1;42:519–522. doi: 10.1007/BF01486678. [DOI] [PubMed] [Google Scholar]
- Samaha F. J., Schroeder J. M., Rebeiz J., Adams R. D. Studies on myotonia. Biochemical and electron microscopic studies on myotonia congenita and myotonia dystrophica. Arch Neurol. 1967 Jul;17(1):22–33. doi: 10.1001/archneur.1967.00470250026003. [DOI] [PubMed] [Google Scholar]
- TAKEUCHI T., KURIAKI H. Histochemical detection of phosphorylase in animal tissues. J Histochem Cytochem. 1955 May;3(3):153–160. doi: 10.1177/3.3.153. [DOI] [PubMed] [Google Scholar]
- Wechsler W. Comparative electron microscopic studies on various forms of muscle atrophies and dystrophies in animals and man. Ann N Y Acad Sci. 1966 Sep 9;138(1):113–137. doi: 10.1111/j.1749-6632.1966.tb41161.x. [DOI] [PubMed] [Google Scholar]