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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1970 Jun;33(3):338–357. doi: 10.1136/jnnp.33.3.338

The central nervous system in motor neurone disease

Betty Brownell 1,1, D R Oppenheimer 1, J Trevor Hughes 1
PMCID: PMC493478  PMID: 5431724

Abstract

Forty-five necropsied cases with primary degeneration of lower motor neurones are described and discussed. Of these, 36 are considered to be `typical' cases of motor neurone disease, eight of which showed no upper motor neurone lesions. The relation of the nine `atypical' cases to the remainder is discussed. It is concluded that motor neurone disease constitutes an ill-defined band in a broad spectrum of multiple system atrophies. The authors have found no evidence suggesting a causal relation between motor neurone disease and either vascular or malignant diseases. They point out suggestive analogies with various subacute encephalomyelopathies in man and other animals.

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Selected References

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  1. BECK E., DANIEL P. M., PARRY H. B. DEGENERATION OF THE CEREBELLAR AND HYPOTHALAMONEUROHYPOPHYSIAL SYSTEMS IN SHEEP WITH SCRAPIE; AND ITS RELATIONSHIP TO HUMAN SYSTEM DEGENERATIONS. Brain. 1964 Mar;87:153–176. doi: 10.1093/brain/87.1.153. [DOI] [PubMed] [Google Scholar]
  2. Beck E., Daniel P. M., Alpers M., Gajdusek D. C., Gibbs C. J., Jr Experimental "kuru" in chimpanzees. A pathological report. Lancet. 1966 Nov 12;2(7472):1056–1059. doi: 10.1016/s0140-6736(66)92031-9. [DOI] [PubMed] [Google Scholar]
  3. Brain L., Croft P. B., Wilkinson M. Motor neurone disease as a manifestation of neoplasm (with a note on the course of classical motor neurone disease). Brain. 1965 Sep;88(3):479–500. doi: 10.1093/brain/88.3.479. [DOI] [PubMed] [Google Scholar]
  4. ENGEL W. K., KURLAND L. T., KLATZO I. An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermediate form? Brain. 1959 Jun;82:203–220. doi: 10.1093/brain/82.2.203. [DOI] [PubMed] [Google Scholar]
  5. FRIEDMAN A. P., FREEDMAN D. Amyotrophic lateral sclerosis. J Nerv Ment Dis. 1950 Jan;111(1):1–18. doi: 10.1097/00005053-195011110-00001. [DOI] [PubMed] [Google Scholar]
  6. Gibbs C. J., Jr, Gajdusek D. C., Asher D. M., Alpers M. P., Beck E., Daniel P. M., Matthews W. B. Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee. Science. 1968 Jul 26;161(3839):388–389. doi: 10.1126/science.161.3839.388. [DOI] [PubMed] [Google Scholar]
  7. Graham J. G., Oppenheimer D. R. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry. 1969 Feb;32(1):28–34. doi: 10.1136/jnnp.32.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hughes J. T., Brownell B. Spinal cord ischemia due to arteriosclerosis. Arch Neurol. 1966 Aug;15(2):189–202. doi: 10.1001/archneur.1966.00470140079011. [DOI] [PubMed] [Google Scholar]
  9. LAWYER T., Jr, NETSKY M. G. Amyotrophic lateral sclerosis. AMA Arch Neurol Psychiatry. 1953 Feb;69(2):171–192. doi: 10.1001/archneurpsyc.1953.02320260029002. [DOI] [PubMed] [Google Scholar]
  10. MULDER D. W. The clinical syndrome of amyotrophic lateral sclerosis. Proc Staff Meet Mayo Clin. 1957 Aug 21;32(17):427–436. [PubMed] [Google Scholar]
  11. MULLER R. Progressive motor neuron disease in adults; a clinical study with special reference to the course of the disease. Acta Psychiatr Neurol Scand. 1952;27(1-2):137–156. doi: 10.1111/j.1600-0447.1952.tb04647.x. [DOI] [PubMed] [Google Scholar]
  12. PATTISON I. H., GORDON W. S., MILLSON G. C. Experimental production of scrapie in goats. J Comp Pathol. 1959 Jul;69:300–312. doi: 10.1016/s0368-1742(59)80029-1. [DOI] [PubMed] [Google Scholar]
  13. SMITH M. C. Observations on the extended use of the Marchi method. J Neurol Neurosurg Psychiatry. 1956 May;19(2):67–73. doi: 10.1136/jnnp.19.2.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. ZILBER L. A., BAJDAKOVA Z. L., GARDASJAN A. N., KONOVALOV N. V., BUNINA T. L., BARABADZE E. M. STUDY OF THE ETIOLOGY OF AMYOTROPHIC LATERAL SCLEROSIS. Bull World Health Organ. 1963;29:449–456. [PMC free article] [PubMed] [Google Scholar]

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