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. 1992 Jun 15;89(12):5680–5684. doi: 10.1073/pnas.89.12.5680

Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA.

J Normanly 1, T Ollick 1, J Abelson 1
PMCID: PMC49356  PMID: 1608979

Abstract

Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.

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Selected References

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