Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1981 Jun;34(6):674–679. doi: 10.1136/jcp.34.6.674

Occurrence of IgM antibodies against BK and JC polyomaviruses during pregnancy.

P E Gibson, A M Field, S D Gardner, D V Coleman
PMCID: PMC493648  PMID: 6265505

Abstract

In a serological survey of 430 pregnant women 45 had high or rising titres of BK-virus haemagglutination-inhibiting antibodies. The presence of BK-virus-specific IgM was confirmed in 10 of these women. No BK-virus-specific IgM was detected in the samples of cord blood from the babies born to these women. The sera from 40 women known to be excreting inclusion-bearing cells during pregnancy were tested for the presence of BK-virus and JC-virus-specific IgM and IgG. The presence of BK-virus-specific IgM was confirmed in three cases and JC-virus-specific IgM in seven cases. Specific IgM persisted for several months in some pregnant women. No Bk-virus-specific IgM was detected in any of the samples of cord blood from the babies born to these women with evidence of polyomavirus infection. No JC-virus-specific IgM was detected in 36 out of 37 of the cord bloods; however, in one it is possible that minute amounts of JC-virus-specific IgM were present.

Full text

PDF
674

Images in this article

676Image
on p.676

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown P., Tsai T., Gajdusek D. C. Seroepidemiology of human papovaviruses. Discovery of virgin populations and some unusual patterns of antibody prevalence among remote peoples of the world. Am J Epidemiol. 1975 Oct;102(4):331–340. doi: 10.1093/oxfordjournals.aje.a112169. [DOI] [PubMed] [Google Scholar]
  2. Coleman D. V., Gardner S. D., Field A. M. Human polyomavirus infection in renal allograft recipients. Br Med J. 1973 Aug 18;3(5876):371–375. doi: 10.1136/bmj.3.5876.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Coleman D. V., Wolfendale M. R., Daniel R. A., Dhanjal N. K., Gardner S. D., Gibson P. E., Field A. M. A prospective study of human polyomavirus infection in pregnancy. J Infect Dis. 1980 Jul;142(1):1–8. doi: 10.1093/infdis/142.1.1. [DOI] [PubMed] [Google Scholar]
  4. Flower A. J., Banatvala J. E., Chrystie I. L. BK antibody and virus-specific IgM responses in renal transplant recipients, patients with malignant disease, and healthy people. Br Med J. 1977 Jul 23;2(6081):220–223. doi: 10.1136/bmj.2.6081.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gardner S. D., Field A. M., Coleman D. V., Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971 Jun 19;1(7712):1253–1257. doi: 10.1016/s0140-6736(71)91776-4. [DOI] [PubMed] [Google Scholar]
  6. Gardner S. D. Prevalence in England of antibody to human polyomavirus (B.k.). Br Med J. 1973 Jan 13;1(5845):77–78. doi: 10.1136/bmj.1.5845.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gaugas J. M., Curzen P. Polyamine interaction with pregnancy serum in suppression of lymphocyte transformation. Lancet. 1978 Jan 7;1(8054):18–20. doi: 10.1016/s0140-6736(78)90363-x. [DOI] [PubMed] [Google Scholar]
  8. Jung M., Krech U., Price P. C., Pyndiah M. N. Evidence of chronic persistent infections with polyomaviruses (BK type) in renal transplant recipients. Arch Virol. 1975;47(1):39–46. doi: 10.1007/BF01315591. [DOI] [PubMed] [Google Scholar]
  9. Kampa D., Schmitz H., Doerr H. W., Luthardt T., Hillemanns H. G., Wurtele A. IgM antibodies to cytomegalovirus during pregnancy. Arch Virol. 1977;53(3):177–184. doi: 10.1007/BF01314662. [DOI] [PubMed] [Google Scholar]
  10. McCance D. J., Mims C. A. Transplacental transmission of polyoma virus in mice. Infect Immun. 1977 Oct;18(1):196–202. doi: 10.1128/iai.18.1.196-202.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mäntyjärvi R. A., Meurman O. H., Vihma L., Berglund B. A human papovavirus (B.K.), biological properties and seroepidemiology. Ann Clin Res. 1973 Oct;5(5):283–287. [PubMed] [Google Scholar]
  12. Noordaa J. V., Wertheim-van Dillen P. Rise in antibodies to human papova virus BK and clinical disease. Br Med J. 1977 Jun 4;1(6074):1471–1471. doi: 10.1136/bmj.1.6074.1471-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Padgett B. L., Walker D. L. Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy. J Infect Dis. 1973 Apr;127(4):467–470. doi: 10.1093/infdis/127.4.467. [DOI] [PubMed] [Google Scholar]
  14. Padgett B. L., Walker D. L., ZuRhein G. M., Eckroade R. J., Dessel B. H. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet. 1971 Jun 19;1(7712):1257–1260. doi: 10.1016/s0140-6736(71)91777-6. [DOI] [PubMed] [Google Scholar]
  15. Portolani M., Marzocchi A., Barbanti-Brodano G., La Placa M. Prevalence in Italy of antibodies to a new human papovavirus (BK virus). J Med Microbiol. 1974 Nov;7(4):543–546. doi: 10.1099/00222615-7-4-543. [DOI] [PubMed] [Google Scholar]
  16. Reese J. M., Reissing M., Daniel R. W., Shah K. V. Occurrence of BK virus and BK virus-specific antibodies in the urine of patients receiving chemotherapy for malignancy. Infect Immun. 1975 Jun;11(6):1375–1381. doi: 10.1128/iai.11.6.1375-1381.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rziha H. J., Belohradsky B. H., Schneider U., Schwenk H. U., Bornkamm G. W., zur Hausen H. BK virus: II. Serologic studies in children with congenital disease and patients with malignant tumors and immunodeficiencies. Med Microbiol Immunol. 1978 Jul 4;165(2):83–92. doi: 10.1007/BF02122743. [DOI] [PubMed] [Google Scholar]
  18. Rziha H. J., Bornkamm G. W., zur Hausen H. BK virus: I. Seroepidemiologic studies and serologic response to viral infection. Med Microbiol Immunol. 1978 Jul 4;165(2):73–81. doi: 10.1007/BF02122742. [DOI] [PubMed] [Google Scholar]
  19. Shah K. V., Daniel R. W., Warszawski R. M. High prevalence of antibodies to BK virus, an SV40-related papovavirus, in residents of Maryland. J Infect Dis. 1973 Dec;128(6):784–787. doi: 10.1093/infdis/128.6.784. [DOI] [PubMed] [Google Scholar]
  20. Shah K. V., Rangan S. R., Reissig M., Daniel R. W., Bellhan F. Z. Congenital transmission of a papovavirus of the stump-tailed macaque. Science. 1977 Jan 28;195(4276):404–406. doi: 10.1126/science.401546. [DOI] [PubMed] [Google Scholar]
  21. Taguchi F., Nagaki D., Saito M., Haruyama C., Iwasaki K. Transplacental transmission of BK virus in human. Jpn J Microbiol. 1975 Oct;19(5):395–398. doi: 10.1111/j.1348-0421.1975.tb00897.x. [DOI] [PubMed] [Google Scholar]
  22. Takemoto K. K., Rabson A. S., Mullarkey M. F., Blaese R. M., Garon C. F., Nelson D. Isolation of papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome. J Natl Cancer Inst. 1974 Nov;53(5):1205–1207. doi: 10.1093/jnci/53.5.1205. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES