Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1971 Feb;34(1):20–22. doi: 10.1136/jnnp.34.1.20

Transitory procaine-induced Parkinsonism

F Gjerris 1
PMCID: PMC493680  PMID: 5551689

Abstract

A case of prolonged, though reversible procaine-induced Parkinsonism treated with l-dopa and trihexyphenidyl (Artane-Sustets) is reported. A pathophysiological explanation is discussed on the basis of recent theories concerning the transmitter systems of the basal ganglia.

Full text

PDF
20

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AYD F. J., Jr A survey of drug-induced extrapyramidal reactions. JAMA. 1961 Mar 25;175:1054–1060. doi: 10.1001/jama.1961.03040120016004. [DOI] [PubMed] [Google Scholar]
  2. CONSTAS C. The effects of adrenaline, noradrenaline, and isoprenaline on parkinsonian tremor. J Neurol Neurosurg Psychiatry. 1962 May;25:116–121. doi: 10.1136/jnnp.25.2.116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cotzias G. C., Papavasiliou P. S., Gellene R. Modification of Parkinsonism--chronic treatment with L-dopa. N Engl J Med. 1969 Feb 13;280(7):337–345. doi: 10.1056/NEJM196902132800701. [DOI] [PubMed] [Google Scholar]
  4. Curzon G. The biochemistry of dyskinesias. Int Rev Neurobiol. 1967;10:323–370. doi: 10.1016/s0074-7742(08)60157-9. [DOI] [PubMed] [Google Scholar]
  5. Duvoisin R. C. Cholinergic-anticholinergic antagonism in parkinsonism. Arch Neurol. 1967 Aug;17(2):124–136. doi: 10.1001/archneur.1967.00470260014002. [DOI] [PubMed] [Google Scholar]
  6. FAURBYE A., RASCH P. J., PETERSEN P. B., BRANDBORG G., PAKKENBERG H. NEUROLOGICAL SYMPTOMS IN PHARMACOTHERAPY OF PSYCHOSES. Acta Psychiatr Scand. 1964;40:10–27. doi: 10.1111/j.1600-0447.1964.tb05731.x. [DOI] [PubMed] [Google Scholar]
  7. FRANK G. B., SANDERS H. D. A PROPOSED COMMON MECHANISM OF ACTION FOR GENERAL AND LOCAL ANAESTHETICS IN THE CENTRAL NERVOUS SYSTEM. Br J Pharmacol Chemother. 1963 Aug;21:1–9. doi: 10.1111/j.1476-5381.1963.tb01497.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gjerris F. Poisoning with chlordiazepoxide (Librium). Dan Med Bull. 1966 Oct;13(6):170–172. [PubMed] [Google Scholar]
  9. HARANATH P. S., AYESHABEGUM N., SITARAMAYYA G. V. THE EFFECTS OF PROCAINE INJECTED INTO THE CEREBRAL VENTRICLES OF CONSCIOUS AND ANAESTHETIZED DOGS. Br J Pharmacol Chemother. 1965 Apr;24:339–347. doi: 10.1111/j.1476-5381.1965.tb01720.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hornykiewicz O. Dopamine (3-hydroxytyramine) and brain function. Pharmacol Rev. 1966 Jun;18(2):925–964. [PubMed] [Google Scholar]
  11. KANE F. J., Jr, MCCURDY R. L. AN UNUSUAL REACTION TO COMBINED LIBRIUM-BARBITURATE THERAPY. Am J Psychiatry. 1964 Feb;120:816–816. doi: 10.1176/ajp.120.8.816. [DOI] [PubMed] [Google Scholar]
  12. KANE F. J., Jr, TAYLOR T. W. A toxic reaction to combined Elavil-Librium therapy. Am J Psychiatry. 1963 Jun;119:1179–1180. doi: 10.1176/ajp.119.12.1179. [DOI] [PubMed] [Google Scholar]
  13. Klawans H. L., Jr The pharmacology of parkinsonism (a review). Dis Nerv Syst. 1968 Dec;29(12):805–816. [PubMed] [Google Scholar]
  14. MACK E. W. INTRATHECAL STEROID ADMINISTRATION. Rocky Mt Med J. 1964 Aug;61:33–34. [PubMed] [Google Scholar]
  15. MCGEER P. L., BOULDING J. E., GIBSON W. C., FOULKES R. G. Drug-induced extrapyramidal reactions. Treatment with diphenhydramine hydrochloride and dihydroxyphenylalanine. JAMA. 1961 Sep 9;177:665–670. doi: 10.1001/jama.1961.03040360001001. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES